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Cruises from USA to Panama

Are you looking for a cruise from USA to Panama? December is the most popular month to cruise between USA and Panama and there are 28 departures available from nine of the world's leading cruise lines.
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21 Cruises (28 Cruise Departures)
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 08 February 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+3 more), Honduras, Costa Rica, Panama
Exclusive Deal
INSIDE
$5,465
OCEANVIEW
$5,999
BALCONY
$8,207
SUITE
$10,741
Save 2,035
From 5,465
View Trip
11 Day Panama Potpourri with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 23 March 2025
Countries Visited: USA, Mexico, Guatemala, Belize (+3 more), Honduras, Costa Rica, Panama
Exclusive Deal
INSIDE
$5,138
OCEANVIEW
$5,514
BALCONY
$7,732
SUITE
$10,266
Save 2,032
From 5,138
View Trip
19 Day Andes & South America with Princess
Cruise
 (3)

19 Days (18 Nights) Los Angeles to Santiago
Cruise Line: Princess
Ship: Majestic Princess
Departure: 01 December 2024
Countries Visited: USA, Mexico, Panama, Peru (+1 more), Chile
INSIDE
$2,334
OCEANVIEW
-
BALCONY
$3,057
SUITE
$3,888
From 2,334
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (4)

11 Days (10 Nights) Fort Lauderdale to Panama City
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2024 to Dec 2025
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$5,440
SUITE
$8,410
Save 1,073
From 5,440
View Trip
11 Day Vivid Western Caribbean with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,028
OCEANVIEW
$5,483
BALCONY
$7,928
SUITE
$10,928
Save 2,032
From 5,028
View Trip
11 Day Panama Canal - Tampa with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Tampa to Panama City
Ship: Norwegian Jade
Departure: 16 January 2026
Countries Visited: USA, Mexico, Belize, Honduras (+3 more), Cayman Islands, Colombia, Panama
Free At Sea OfferExclusive Solo Offer
INSIDE
$3,028
OCEANVIEW
$3,484
BALCONY
$4,698
SUITE
$5,078
From 3,028
View Trip
12 Day Los Angeles to Panama City with Silversea
Cruise

12 Days (11 Nights) Los Angeles to Panama City
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 09 May 2025
Countries Visited: USA, Mexico, Costa Rica, Panama
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$6,138
BALCONY
$7,326
SUITE
-
From 6,138
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Fort Lauderdale to Santiago
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Oct 2024 to Oct 2025
Countries Visited: USA, Mexico, Panama, Ecuador (+2 more), Peru, Chile
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$14,845
SUITE
$20,785
Save 1,150
From 14,845
View Trip
13 Day Tropical Waters And Remote Island Communities In The Caribbean with Hurtigruten
Cruise

13 Days (12 Nights) Miami to Colon
Cruise Line: Hurtigruten
Ship: MS Roald Amundsen
Departure: 25 September 2024
Countries Visited: USA, Belize, Honduras, Nicaragua (+1 more), Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
$11,640
BALCONY
$13,561
SUITE
$15,646
Save 3,520
From 11,640
View Trip
16 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 04 January 2025
Countries Visited: USA, Dominican Republic, Puerto Rico, Virgin Islands (+7 more), Saint Lucia, Trinidad and Tobago, Grenada, Aruba, Colombia, Panama, Costa Rica
Free At Sea OfferExclusive Solo Offer
INSIDE
$3,578
OCEANVIEW
$4,079
BALCONY
$5,886
SUITE
$6,311
From 3,578
View Trip
13 Day Majestic Beaches & Canal Crossing with Regent Seven Seas
Cruise

13 Days (12 Nights) Miami to Panama City
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 03 January 2026
Countries Visited: USA, Cayman Islands, Jamaica, Bonaire (+5 more), Curacao, Aruba, Colombia, Costa Rica, Panama
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$11,690
SUITE
$12,363
Save 5,850
From 11,690
View Trip
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Galveston to Panama City
Ship: Norwegian Jade
Departure: 06 February 2026
Countries Visited: USA, Mexico, Belize, Honduras (+3 more), Cayman Islands, Colombia, Panama
Free At Sea Offer
INSIDE
$3,100
OCEANVIEW
$3,511
BALCONY
$4,801
SUITE
$5,225
From 3,100
View Trip
11 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 12 December 2025
Countries Visited: USA, Mexico, Belize, Honduras (+3 more), Cayman Islands, Colombia, Panama
Free At Sea OfferExclusive Solo Offer
INSIDE
$3,087
OCEANVIEW
$3,543
BALCONY
$4,757
SUITE
$5,137
From 3,087
View Trip
13 Day A Journey Of Pacific Pleasures And The Panama Canal with Explora Journeys
Cruise

13 Days (12 Nights) Los Angeles to Panama City
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 12 May 2024
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+1 more), Panama
The Total Luxury OfferExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,554
SUITE
$9,217
From 7,554
View Trip
19 Day An Extended Journey Tracing North America's Pacific Shore with Explora Journeys
Cruise

19 Days (18 Nights) Vancouver to Panama City
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 06 May 2024
Countries Visited: Canada, USA, Mexico, Guatemala (+2 more), Costa Rica, Panama
The Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$11,677
SUITE
$14,241
From 11,677
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Gem
Departure: 02 December 2024
Countries Visited: USA, Dominican Republic, Curacao, Aruba (+1 more), Panama
Free At Sea OfferExclusive Solo Offer
INSIDE
$2,438
OCEANVIEW
$2,666
BALCONY
$3,835
SUITE
$3,986
From 2,438
View Trip
11 Day Palms & Panama Canal with Oceania Cruises
Cruise

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 01 November 2025
Countries Visited: USA, Dominican Republic, Aruba, Colombia (+1 more), Panama
Free At Sea OfferExclusive Solo Offer
INSIDE
$2,735
OCEANVIEW
$3,191
BALCONY
$4,329
SUITE
$4,632
From 2,735
View Trip
11 Day Panama Canal Voyage with Azamara Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 03 December 2024
Countries Visited: USA, Aruba, Bonaire, Curacao (+2 more), Colombia, Panama
INSIDE
$3,983
OCEANVIEW
$4,345
BALCONY
$5,206
SUITE
$7,506
From 3,983
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Los Angeles to Colon
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 02 November 2025
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,979
OCEANVIEW
$6,514
BALCONY
$9,414
SUITE
$13,117
Save 2,041
From 5,979
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Tampa to Panama City
Ship: Norwegian Jade
Departure: 29 January 2025
Countries Visited: USA, Mexico, Cayman Islands, Jamaica (+3 more), Colombia, Panama, Costa Rica
Free At Sea Offer
INSIDE
$2,834
OCEANVIEW
$3,289
BALCONY
$4,655
SUITE
$4,883
From 2,834
View Trip
Results: 21 results

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