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Panama Tours & Cruises Starting In November 2025

If you're looking at joining a tour to Panama in November 2025, we have 31 unique cruises, small group tours and adventures with 250 departures from the world's leading tour operators departing in November.
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Departures (November 2025)
< October 2025 December 2025 >
Duration
10 Days
54 Days
Types
Budget
Start & End Cities
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Price
$1,400pp
$132,495pp
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31 Trips (250 Trip Departures)
12 Day Costa Rica & Panama Discovery with Intrepid Travel
Tour

12 Days San Jose to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Costa Rica, Panama
Limited Time Sale
Save 208
From 1,702
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14 Day Cycle Nicaragua to the Panama Canal with Explore!
Tour

14 Days Granada to Panama City
Operated By: Explore!
Departures: Oct 2024 to Nov 2025
Trip Styles: Adventure, Small Group, Cycling
Countries Visited: Costa Rica, Panama, Nicaragua
Exclusive Savings
Save 147
From 7,203
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10 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Miami to Panama City
Ship: Norwegian Jade
Departure: 01 November 2025
Countries Visited: USA, Dominican Republic, Aruba, Colombia (+1 more), Panama
Free At Sea OfferExclusive Solo Offer
INSIDE
$2,735
OCEANVIEW
$3,191
BALCONY
$4,329
SUITE
$4,632
From 2,735
View Trip
17 Day Panama Canal - Ocean to Ocean Holiday with Princess
Cruise
 (2)

17 Days (16 Nights) Fort Lauderdale to San Francisco
Cruise Line: Princess
Ship: Island Princess
Departure: 21 November 2025
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Guatemala, Mexico
INSIDE
$2,989
OCEANVIEW
$3,295
BALCONY
$4,446
SUITE
$5,099
From 2,989
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2024 to Dec 2025
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$5,638
SUITE
$8,905
Save 1,073
From 5,638
View Trip
18 Day Panama Canal & Inca Discovery with Holland America
Cruise
 (1)

18 Days (17 Nights) Fort Lauderdale to San Antonio
Cruise Line: Holland America
Ship: Oosterdam
Departures: Nov 2024 to Nov 2025
Countries Visited: USA, Cayman Islands, Panama, Ecuador (+2 more), Peru, Chile
Have It All Offer
INSIDE
$4,223
OCEANVIEW
$4,371
BALCONY
$5,549
SUITE
$7,212
From 4,223
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$5,977
OCEANVIEW
$6,511
BALCONY
$9,412
SUITE
$13,115
Save 2,043
From 5,977
View Trip
25 Day Central American Explorer with Explore!
Tour

25 Days Panama City to Antigua
Operated By: Explore!
Departures: Jan 2025 to Nov 2025
Trip Styles: Adventure, Small Group
Countries Visited: Panama, Costa Rica, Nicaragua, El Salvador (+2 more), Honduras, Guatemala
Exclusive Savings
Save 176
From 8,399
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Emerald Princess
Departure: 02 November 2025
Countries Visited: USA, Aruba, Panama, Costa Rica (+2 more), Nicaragua, Mexico
INSIDE
$2,719
OCEANVIEW
$2,980
BALCONY
$4,244
SUITE
$5,040
From 2,719
View Trip
13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Los Angeles to Colon
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 02 November 2025
Countries Visited: USA, Mexico, Guatemala, Nicaragua (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,979
OCEANVIEW
$6,514
BALCONY
$9,414
SUITE
$13,117
Save 2,041
From 5,979
View Trip
28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
Limited Time Sale
Save 655
From 3,480
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16 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Miami to Los Angeles
Ships: Norwegian Bliss, Norwegian Encore
Departures: Nov 2025 to Feb 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Guatemala, Mexico
Free At Sea Offer
INSIDE
$4,213
OCEANVIEW
$5,199
BALCONY
$6,262
SUITE
$7,097
From 4,213
View Trip
13 Day Panama Canal Sunfarer with Holland America
Cruise
 (2)

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departures: Nov 2025 to Dec 2025
Countries Visited: USA, Bahamas, Curacao, Colombia (+3 more), Panama, Costa Rica, Jamaica
Have It All Offer
INSIDE
$3,677
OCEANVIEW
$4,618
BALCONY
$5,014
SUITE
$6,449
From 3,677
View Trip
15 Day Panama Canal & Central America with Viking Cruises
Cruise
 (4)

15 Days (14 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Nov 2024 to Feb 2026
Countries Visited: USA, Jamaica, Panama, Costa Rica (+3 more), Honduras, Belize, Mexico
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$7,420
SUITE
$12,667
Save 1,093
From 7,420
View Trip
13 Day Panama Canal with Costa Rica & Caribbean with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departures: Nov 2025 to Feb 2026
Countries Visited: USA, Cayman Islands, Jamaica, Costa Rica (+3 more), Panama, Aruba, Curacao
INSIDE
$2,091
OCEANVIEW
$2,139
BALCONY
$3,239
SUITE
$4,160
From 2,091
View Trip
12 Day Central America with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Miami to Miami
Ships: Norwegian Gem, Norwegian Jade
Departures: Nov 2024 to Dec 2025
Countries Visited: USA, Cayman Islands, Colombia, Panama (+3 more), Costa Rica, Belize, Mexico
Free At Sea Offer
INSIDE
$3,429
OCEANVIEW
$3,883
BALCONY
$5,452
SUITE
$5,953
From 3,429
View Trip
13 Day Panama Canal with Costa Rica & Caribbean Holiday with Princess
Cruise

13 Days (12 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 17 November 2025
Countries Visited: USA, Aruba, Curacao, Colombia (+3 more), Panama, Costa Rica, Jamaica
INSIDE
$2,098
OCEANVIEW
$2,149
BALCONY
$3,246
SUITE
$4,177
From 2,098
View Trip
13 Day Maya Magnificence with Oceania Cruises
Cruise

13 Days (12 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 28 November 2025
Countries Visited: USA, Mexico, Guatemala, Panama (+3 more), Costa Rica, Honduras, Belize
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,192
SUITE
$9,905
Save 2,058
From 7,192
View Trip
44 Day Best of Central America with Intrepid Travel
Tour
 (1)

44 Days Playa del Carmen to Panama City
Operated By: Intrepid Travel
Departures: May 2024 to Nov 2025
Trip Styles: Adventure, Small Group
Countries Visited: Mexico, Belize, Guatemala, Honduras (+4 more), El Salvador, Nicaragua, Costa Rica, Panama
Limited Time Sale
Save 758
From 6,192
View Trip
11 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Miami
Ship: Norwegian Jade
Departure: 10 November 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Free At Sea Offer
INSIDE
$3,091
OCEANVIEW
$3,547
BALCONY
$4,761
SUITE
$5,141
From 3,091
View Trip
22 Day Panama Canal & Southern Caribbean: ABC Islands with Holland America
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departure: 16 November 2025
Countries Visited: USA, Bahamas, Curacao, Colombia (+5 more), Panama, Costa Rica, Jamaica, Aruba, Bonaire
Have It All Offer
INSIDE
$5,837
OCEANVIEW
$7,174
BALCONY
$7,768
SUITE
$9,995
From 5,837
View Trip
22 Day Southern Caribbean & Panama Canal: ABC Islands with Holland America
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departures: Nov 2025 to Dec 2025
Countries Visited: USA, Curacao, Bonaire, Aruba (+5 more), Bahamas, Colombia, Panama, Costa Rica, Jamaica
Have It All Offer
INSIDE
$5,986
OCEANVIEW
$7,322
BALCONY
$7,916
SUITE
$10,094
From 5,986
View Trip
32 Day Panama Canal, Inca & South America Discovery with Holland America
Cruise
 (1)

32 Days (31 Nights) Fort Lauderdale to Buenos Aires
Cruise Line: Holland America
Ship: Oosterdam
Departures: Nov 2024 to Nov 2025
Countries Visited: USA, Cayman Islands, Panama, Ecuador (+5 more), Peru, Chile, Argentina, Falkland Islands, Uruguay
Have It All Offer
INSIDE
$7,491
OCEANVIEW
$7,749
BALCONY
$9,590
SUITE
$12,332
From 7,491
View Trip
22 Day Southern Caribbean & Panama Canal: ABC Islands with Holland America
Cruise
 (2)

22 Days (21 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Holland America
Ship: Rotterdam
Departure: 28 November 2025
Countries Visited: USA, Curacao, Aruba, Bonaire (+5 more), Bahamas, Colombia, Panama, Costa Rica, Cayman Islands
Have It All Offer
INSIDE
$5,689
OCEANVIEW
$7,025
BALCONY
$7,619
SUITE
$9,896
From 5,689
View Trip
37 Day Andes & Cape Horn Grand Adventure with Princess
Cruise

37 Days (36 Nights) Los Angeles to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 16 November 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+6 more), Ecuador, Peru, Chile, Argentina, Falkland Islands, Uruguay
INSIDE
$9,431
OCEANVIEW
$9,351
BALCONY
$12,648
SUITE
$15,489
From 9,351
View Trip
54 Day Ultimate Antarctica & South America Adventure with Princess
Cruise

54 Days (53 Nights) Los Angeles to Buenos Aires
Cruise Line: Princess
Ship: Sapphire Princess
Departure: 16 November 2025
Countries Visited: USA, Mexico, Costa Rica, Panama (+7 more), Ecuador, Peru, Chile, Argentina, Falkland Islands, Uruguay, Antarctica
INSIDE
$14,708
OCEANVIEW
$14,926
BALCONY
$20,153
SUITE
$24,440
From 14,708
View Trip
17 Day Southern Caribbean Beauty with Regent Seven Seas
Cruise

17 Days (16 Nights) Miami to Bridgetown
Cruise Line: Regent Seven Seas
Ship: Seven Seas Splendor
Departure: 17 November 2025
Countries Visited: USA, Mexico, Belize, Honduras (+8 more), Costa Rica, Panama, Colombia, Aruba, Curacao, Bonaire, Grenada, Barbados
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,878
SUITE
$15,016
Save 7,062
From 12,878
View Trip
43 Day Iconic Isles To Icebergs with Oceania Cruises
Cruise

43 Days (42 Nights) Miami to Buenos Aires
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 29 November 2025
Countries Visited: USA, Mexico, Belize, Guatemala (+9 more), Honduras, Costa Rica, Panama, Ecuador, Peru, Chile, Argentina, Antarctica, Falkland Islands
Exclusive Deal
INSIDE
$18,251
OCEANVIEW
$21,003
BALCONY
$23,756
SUITE
$34,368
Save 2,129
From 18,251
View Trip
24 Day Collectors Caribbean with Oceania Cruises
Cruise

24 Days (23 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 28 November 2025
Countries Visited: USA, Mexico, Guatemala, Panama (+10 more), Costa Rica, Honduras, Belize, Bahamas, Puerto Rico, Saint Kitts and Nevis, Barbados, Saint Lucia, Antigua and Barbuda, Virgin Islands
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,770
SUITE
$18,175
Save 2,100
From 12,770
View Trip
25 Day Caribbean Spectrum with Oceania Cruises
Cruise

25 Days (24 Nights) Miami to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Allura
Departure: 16 November 2025
Countries Visited: USA, Aruba, Curacao, Bonaire (+10 more), Grenada, Saint Lucia, Saint Barthelemy, Virgin Islands, Mexico, Guatemala, Panama, Costa Rica, Honduras, Belize
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,265
SUITE
$18,829
Save 2,105
From 13,265
View Trip
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