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Cruises From Panama City

Choose from 18 unique cruises starting in Panama City, and travelling to Fort Lauderdale, Galveston, Los Angeles, Miami, New York and more. December and February are the most popular months to join a cruise from Panama City and you can select from 22 departures available from eight leading cruise lines.
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18 Cruises (22 Cruise Departures)
11 Day Captivating Panama Canal with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 02 April 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+3 more), Bonaire, Jamaica, USA
Exclusive Deal
INSIDE
$5,147
OCEANVIEW
$5,533
BALCONY
$7,751
SUITE
$10,285
Save 2,033
From 5,147
View Trip
11 Day Classic Panama Canal Passage with Viking Cruises
Cruise
 (4)

11 Days (10 Nights) Panama City to Fort Lauderdale
Cruise Line: Viking Cruises
Ship: Viking Mars
Departures: Oct 2024 to Dec 2025
Countries Visited: Panama, Costa Rica, Honduras, Belize (+2 more), Mexico, USA
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$5,638
SUITE
$8,905
Save 1,074
From 5,638
View Trip
12 Day Classic Panama Canal with Oceania Cruises
Cruise
 (2)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Bonaire, Jamaica, Bahamas, USA
Exclusive Deal
INSIDE
$5,931
OCEANVIEW
$6,386
BALCONY
$9,217
SUITE
$12,217
Save 2,039
From 5,931
View Trip
12 Day Caribbean Quest Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 15 March 2026
Countries Visited: Panama, Colombia, Aruba, Bonaire (+3 more), Curacao, Dominican Republic, USA
INSIDE
$3,963
OCEANVIEW
$4,884
BALCONY
$5,803
SUITE
$6,723
From 3,963
View Trip
8 Day A Journey Traversing The Panama Canal with Explora Journeys
Cruise

8 Days (7 Nights) Panama City to Miami
Cruise Line: Explora Journeys
Ship: Explora I
Departure: 24 May 2024
Countries Visited: Panama, Colombia, USA
Exclusive DealThe Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,593
SUITE
$6,519
From 5,593
View Trip
12 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Miami
Ship: Norwegian Jade
Departure: 09 February 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
Free At Sea OfferExclusive Solo Offer
INSIDE
$2,814
OCEANVIEW
$3,330
BALCONY
$4,832
SUITE
$5,136
From 2,814
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
14 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

14 Days (13 Nights) Panama City to New York
Ship: Norwegian Jade
Departure: 22 December 2025
Countries Visited: Panama, Colombia, Aruba, Curacao (+5 more), Saint Lucia, Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
Free At Sea OfferExclusive Solo Offer
INSIDE
$4,531
OCEANVIEW
$5,290
BALCONY
$7,187
SUITE
$8,327
From 4,531
View Trip
11 Day Tropical Tastes Of The Riviera with Regent Seven Seas
Cruise

11 Days (10 Nights) Panama City to Los Angeles
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 15 January 2026
Countries Visited: Panama, Costa Rica, Nicaragua, Mexico (+1 more), USA
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,618
SUITE
$10,143
Save 6,132
From 9,618
View Trip
10 Day Panama Canal Voyage with Azamara Cruises
Cruise

10 Days (9 Nights) Panama City to Miami
Cruise Line: Azamara Cruises
Ship: Azamara Journey
Departure: 13 December 2024
Countries Visited: Panama, Costa Rica, Honduras, Guatemala (+2 more), Mexico, USA
Circle Club Voyage
INSIDE
$3,180
OCEANVIEW
$3,361
BALCONY
$4,138
SUITE
$5,689
From 3,180
View Trip
12 Day The Panama Canal & Costa Rica - Westbound with Tauck
Cruise

12 Days (11 Nights) Panama City to San Jose
Operated By: Tauck
Departure: 18 January 2025
Trip Styles: Group, Cruise
Countries Visited: Panama, Costa Rica
From 14,250
View Trip
11 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Miami
Ship: Norwegian Jade
Departure: 10 November 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Free At Sea Offer
INSIDE
$3,091
OCEANVIEW
$3,547
BALCONY
$4,761
SUITE
$5,141
From 3,091
View Trip
10 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

10 Days (9 Nights) Panama City to Miami
Ship: Norwegian Gem
Departure: 11 December 2024
Countries Visited: Panama, Costa Rica, Jamaica, Cayman Islands (+3 more), Mexico, Bahamas, USA
Free At Sea Offer
INSIDE
$2,355
OCEANVIEW
$2,628
BALCONY
$3,690
SUITE
$3,873
From 2,355
View Trip
8 Day Panama City to Fort Lauderdale with Silversea
Cruise

8 Days (7 Nights) Panama City to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Shadow
Departure: 20 May 2025
Countries Visited: Panama, Colombia, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
$4,158
BALCONY
$5,049
SUITE
-
From 4,158
View Trip
11 Day Classic Canal & Tropics with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 04 April 2026
Countries Visited: Panama, Colombia, Curacao, Aruba (+3 more), Jamaica, Cayman Islands, USA
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
12 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Galveston
Ship: Norwegian Jade
Departure: 26 January 2026
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Free At Sea Offer
INSIDE
$3,272
OCEANVIEW
$3,804
BALCONY
$5,170
SUITE
$5,672
From 3,272
View Trip
11 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Panama City to Tampa
Ship: Norwegian Jade
Departure: 19 January 2025
Countries Visited: Panama, Colombia, Jamaica, Cayman Islands (+4 more), Honduras, Belize, Mexico, USA
Free At Sea Offer
INSIDE
$2,675
OCEANVIEW
$2,934
BALCONY
$4,316
SUITE
$4,589
From 2,675
View Trip
12 Day Panama Canal - Panama City with Norwegian Cruise Line
Cruise

12 Days (11 Nights) Panama City to Miami
Ship: Norwegian Jade
Departure: 16 February 2026
Countries Visited: Panama, Colombia, Aruba, Saint Lucia (+4 more), Saint Kitts and Nevis, Virgin Islands, Dominican Republic, USA
Free At Sea Offer
INSIDE
$3,234
OCEANVIEW
$3,765
BALCONY
$5,253
SUITE
$5,633
From 3,234
View Trip
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