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All Panama Tours & Cruises

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231 Trips (568 Trip Departures)
25 Day Central American Explorer with Explore!
Tour

25 Days Panama City to Antigua
Operated By: Explore!
Departures: Jan 2025 to Nov 2025
Trip Styles: Adventure, Small Group
Countries Visited: Panama, Costa Rica, Nicaragua, El Salvador (+2 more), Honduras, Guatemala
Exclusive Savings
Save 176
From 8,399
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16 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Miami to Los Angeles
Ships: Norwegian Bliss, Norwegian Encore
Departures: Nov 2025 to Feb 2026
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Guatemala, Mexico
Exclusive Solo Offer
INSIDE
$3,602
OCEANVIEW
$4,597
BALCONY
$5,667
SUITE
$6,509
From 3,602
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12 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 26 January 2025
Countries Visited: USA, Costa Rica, Panama, Colombia (+2 more), Aruba, Cayman Islands
Exclusive Deal
INSIDE
$2,022
OCEANVIEW
-
BALCONY
$5,164
SUITE
$10,812
Save 812
From 1,876
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16 Day Panama Canal Cruise with Royal Caribbean
Cruise

16 Days (15 Nights) Tampa to Los Angeles
Cruise Line: Royal Caribbean
Ship: Radiance of the Seas
Departure: 19 April 2025
Countries Visited: USA, Cayman Islands, Colombia, Panama (+2 more), Guatemala, Mexico
Exclusive Deal
INSIDE
$2,848
OCEANVIEW
$3,258
BALCONY
$4,384
SUITE
-
Save 904
From 2,504
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15 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

15 Days (14 Nights) San Diego to Miami
Ship: Norwegian Jade
Departure: 18 October 2025
Countries Visited: USA, Mexico, Guatemala, Panama (+2 more), Colombia, Cayman Islands
Exclusive Solo Offer
INSIDE
$3,619
OCEANVIEW
$4,308
BALCONY
$6,066
SUITE
$6,830
From 3,619
View Trip
16 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Los Angeles to Miami
Ships: Norwegian Bliss, Norwegian Joy
Departures: Dec 2024 to Feb 2025
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
INSIDE
$3,013
OCEANVIEW
$3,442
BALCONY
$4,391
SUITE
$4,666
From 3,013
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12 Day Panama Canal & Southern Caribbean with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 02 February 2026
Countries Visited: USA, Colombia, Panama, Aruba (+2 more), Curacao, Cayman Islands
Exclusive Offer
INSIDE
$2,841
OCEANVIEW
$3,433
BALCONY
$3,958
SUITE
$10,043
Save 3,433
From 2,841
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19 Day Fort Lauderdale to Los Angeles with Silversea
Cruise

19 Days (18 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Silversea
Ship: Silver Moon
Departure: 01 April 2025
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Guatemala, Mexico
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$13,662
BALCONY
$15,147
SUITE
$26,334
From 13,662
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11 Day Vivid Western Caribbean with Oceania Cruises
Cruise

11 Days (10 Nights) Miami to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 14 April 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,028
OCEANVIEW
$5,483
BALCONY
$7,928
SUITE
$10,928
Save 2,032
From 5,028
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17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Orlando to Los Angeles
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 14 April 2025
Countries Visited: USA, Bahamas, Colombia, Panama (+2 more), Costa Rica, Mexico
INSIDE
$2,424
OCEANVIEW
$2,650
BALCONY
$3,651
SUITE
$5,413
From 2,424
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12 Day Southern Caribbean & Perfect Day with Royal Caribbean
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 05 January 2025
Countries Visited: USA, Costa Rica, Panama, Colombia (+2 more), Aruba, Bahamas
Exclusive Deal
INSIDE
$2,354
OCEANVIEW
$3,495
BALCONY
$3,712
SUITE
$10,570
Save 897
From 2,064
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13 Day Pacific Pathways with Oceania Cruises
Cruise

13 Days (12 Nights) Colon to Los Angeles
Cruise Line: Oceania Cruises
Ship: Oceania Regatta
Departure: 14 November 2025
Countries Visited: Panama, Costa Rica, Nicaragua, Guatemala (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$5,977
OCEANVIEW
$6,511
BALCONY
$9,412
SUITE
$13,115
Save 2,043
From 5,977
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16 Day Panama Canal with Holland America
Cruise

16 Days (15 Nights) San Diego to Miami
Cruise Line: Holland America
Ship: Zuiderdam
Departure: 27 February 2026
Countries Visited: USA, Mexico, Guatemala, Panama (+2 more), Colombia, Bahamas
Have It All Offer
INSIDE
$5,187
OCEANVIEW
$5,682
BALCONY
$6,870
SUITE
$8,652
From 5,187
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16 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Los Angeles to Miami
Ships: Norwegian Bliss, Norwegian Encore (+1 more), Norwegian Joy
Departures: Oct 2025 to Feb 2026
Countries Visited: USA, Mexico, Guatemala, Costa Rica (+2 more), Panama, Colombia
Exclusive Solo Offer
INSIDE
$3,567
OCEANVIEW
$4,561
BALCONY
$5,139
SUITE
$5,903
From 3,567
View Trip
17 Day Panama Canal - Miami with Norwegian Cruise Line
Cruise

17 Days (16 Nights) Miami to Los Angeles
Ship: Norwegian Joy
Departure: 21 January 2025
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Guatemala, Mexico
INSIDE
$3,518
OCEANVIEW
$4,543
BALCONY
$5,537
SUITE
$5,782
From 3,518
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11 Day Palms & Panama Canal with Oceania Cruises
Cruise

11 Days (10 Nights) Tampa to Panama City
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 25 March 2026
Countries Visited: USA, Mexico, Belize, Honduras (+2 more), Costa Rica, Panama
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
18 Day Panama & Scenic South America with Viking Cruises
Cruise

18 Days (17 Nights) Santiago to Fort Lauderdale
Cruise Line: Viking Cruises
Ships: Viking Octantis, Viking Polaris
Departures: Mar 2025 to Mar 2025
Countries Visited: Chile, Peru, Ecuador, Panama (+2 more), Mexico, USA
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$15,340
SUITE
$22,765
Save 1,160
From 15,340
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12 Day Panama Canal & Southern Caribbean with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ships: Celebrity Ascent, Celebrity Beyond
Departures: Jan 2025 to Mar 2026
Countries Visited: USA, Colombia, Panama, Aruba (+2 more), Curacao, Bonaire
Exclusive Offer
INSIDE
$2,714
OCEANVIEW
$2,940
BALCONY
$3,941
SUITE
$10,110
Save 3,676
From 2,714
View Trip
11 Day Canal & Coral Isles with Oceania Cruises
Cruise

11 Days (10 Nights) Panama City to Miami
Cruise Line: Oceania Cruises
Ship: Oceania Insignia
Departure: 24 April 2026
Countries Visited: Panama, Colombia, Costa Rica, Honduras (+2 more), Mexico, USA
Exclusive Deal
INSIDE
$5,026
OCEANVIEW
$5,482
BALCONY
$7,927
SUITE
$10,927
Save 2,034
From 5,026
View Trip
12 Day Canal & South Caribbean with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Beyond
Departure: 17 March 2025
Countries Visited: USA, Colombia, Panama, Bonaire (+2 more), Aruba, Cayman Islands
Exclusive Offer
INSIDE
$2,262
OCEANVIEW
$2,823
BALCONY
$3,403
SUITE
$10,114
Save 3,082
From 2,262
View Trip
17 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

17 Days (16 Nights) Los Angeles to Miami
Ship: Norwegian Joy
Departure: 05 January 2025
Countries Visited: USA, Mexico, Guatemala, Panama (+2 more), Colombia, Cayman Islands
INSIDE
$3,231
OCEANVIEW
$3,796
BALCONY
$4,607
SUITE
$5,326
From 3,231
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Los Angeles to Fort Lauderdale
Cruise Line: Princess
Ship: Caribbean Princess
Departure: 30 September 2025
Countries Visited: USA, Mexico, Nicaragua, Costa Rica (+2 more), Panama, Aruba
INSIDE
$2,752
OCEANVIEW
$3,014
BALCONY
$4,138
SUITE
$5,980
From 2,752
View Trip
14 Day Fort Lauderdale to Lima with Silversea
Cruise

14 Days (13 Nights) Fort Lauderdale to Lima
Cruise Line: Silversea
Ship: Silver Dawn
Departure: 06 January 2026
Countries Visited: USA, Mexico, Costa Rica, Panama (+2 more), Ecuador, Peru
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$15,493
BALCONY
$16,780
SUITE
$32,026
From 15,493
View Trip
12 Day Canal & Caribbean Holiday with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Beyond
Departure: 23 December 2024
Countries Visited: USA, Colombia, Panama, Bonaire (+2 more), Aruba, Curacao
Exclusive Offer
INSIDE
$4,473
OCEANVIEW
$4,888
BALCONY
$7,607
SUITE
$13,638
Save 4,556
From 4,473
View Trip
16 Day Panama Canal Repositioning Cruise with Norwegian Cruise Line
Cruise

16 Days (15 Nights) Miami to Los Angeles
Ship: Norwegian Bliss
Departure: 22 February 2025
Countries Visited: USA, Colombia, Panama, Costa Rica (+2 more), Guatemala, Mexico
INSIDE
$3,415
OCEANVIEW
$4,486
BALCONY
$5,556
SUITE
$6,322
From 3,415
View Trip
17 Day Panama Canal - Ocean to Ocean with Princess
Cruise

17 Days (16 Nights) Fort Lauderdale to Los Angeles
Cruise Line: Princess
Ship: Emerald Princess
Departure: 02 November 2025
Countries Visited: USA, Aruba, Panama, Costa Rica (+2 more), Nicaragua, Mexico
INSIDE
$2,719
OCEANVIEW
$2,980
BALCONY
$4,244
SUITE
$5,040
From 2,719
View Trip
9 Day Cartagena to Fort Lauderdale with Silversea
Cruise

9 Days (8 Nights) Cartagena to Fort Lauderdale
Cruise Line: Silversea
Ship: Silver Moon
Departure: 29 December 2024
Countries Visited: Belize, Colombia, Honduras, Mexico (+2 more), Panama, USA
Port-to-PortExclusive Solo Offer
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$25,938
From 25,938
View Trip
12 Day Panama Canal & Southern Caribbean with Celebrity Cruises
Cruise

12 Days (11 Nights) Fort Lauderdale to Fort Lauderdale
Cruise Line: Celebrity Cruises
Ship: Celebrity Beyond
Departure: 02 December 2024
Countries Visited: USA, Colombia, Panama, Aruba (+2 more), Bonaire, Cayman Islands
Exclusive Offer
INSIDE
$2,369
OCEANVIEW
$3,177
BALCONY
$4,235
SUITE
$11,134
Save 3,136
From 2,369
View Trip
12 Day Southern Caribbean Cruise with Royal Caribbean
Cruise

12 Days (11 Nights) Miami to Miami
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departures: Nov 2024 to Mar 2025
Countries Visited: USA, Costa Rica, Panama, Colombia (+2 more), Aruba, Curacao
Exclusive Deal
INSIDE
$2,035
OCEANVIEW
$2,438
BALCONY
$3,364
SUITE
$5,243
Save 988
From 1,901
View Trip
28 Day Amazing Central America with Intrepid Travel
Tour

28 Days Antigua to Panama City
Operated By: Intrepid Travel
Departures: Jun 2024 to Dec 2025
Trip Styles: Adventure, Small Group
Countries Visited: Guatemala, Honduras, El Salvador, Nicaragua (+2 more), Costa Rica, Panama
Limited Time Sale
Save 763
From 3,480
View Trip
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