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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 230 departures available from sixteen of the world's leading cruise lines.
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31 Days
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129 Cruises (230 Cruise Departures)
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 July 2024
Countries Visited: Italy, France, Spain
INSIDE
$1,595
OCEANVIEW
$1,704
BALCONY
$2,150
SUITE
$4,120
From 1,595
View Trip
13 Day Mediterranean Tapestry with Oceania Cruises
Cruise

13 Days (12 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 29 June 2024
Countries Visited: Italy, Croatia, Montenegro, Greece (+5 more), Sicily, Corsica, Monaco, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,271
SUITE
$13,974
Save 2,089
From 10,271
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Valencia
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 05 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$804
OCEANVIEW
$933
BALCONY
$1,111
SUITE
-
From 804
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 14 June 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
INSIDE
$4,086
OCEANVIEW
$5,361
BALCONY
$5,816
SUITE
$7,351
From 4,086
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 18 June 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$680
SUITE
-
From 680
View Trip
9 Day Civitavecchia to Barcelona with Silversea
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 23 September 2025
Countries Visited: Italy, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$12,078
From 12,078
View Trip
8 Day A Journey Of Storied Italian Islands and Starry Spanish Nights with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 19 August 2024
Countries Visited: Italy, Sicily, Sardinia, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,019
SUITE
$9,751
From 6,014
View Trip
18 Day Mediterranean Majesty with Regent Seven Seas
Cruise

18 Days (17 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 17 October 2024
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, Morocco
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$24,403
SUITE
$28,096
Save 5,227
From 24,403
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 09 June 2025
Countries Visited: Italy, Corsica, Spain
INSIDE
$1,338
OCEANVIEW
$1,556
BALCONY
$1,783
SUITE
$3,744
From 1,338
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 27 September 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
INSIDE
$4,050
OCEANVIEW
$5,054
BALCONY
$6,430
SUITE
$7,499
From 4,050
View Trip
10 Day Wonders Of Spain with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,644
SUITE
$13,465
Save 5,266
From 12,644
View Trip
15 Day Spain, Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 June 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
INSIDE
$3,172
OCEANVIEW
$3,518
BALCONY
$3,964
SUITE
$8,518
From 3,172
View Trip
13 Day Greek Isles, Italy & Turkey with Celebrity Cruises
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 23 September 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive DealExclusive Offer
INSIDE
$3,619
OCEANVIEW
-
BALCONY
$11,889
SUITE
$11,569
Save 4,305
From 3,619
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 06 July 2026
Countries Visited: Italy, Croatia, Malta, France (+2 more), Corsica, Spain
INSIDE
$4,610
OCEANVIEW
$4,956
BALCONY
$5,946
SUITE
$12,381
From 4,610
View Trip
12 Day A Journey From Rome To Barcelona with Explora Journeys
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 April 2025
Countries Visited: Italy, Spain, Morocco, Gibraltar
INSIDE
-
OCEANVIEW
-
BALCONY
$10,251
SUITE
$12,509
From 8,093
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 04 August 2025
Countries Visited: Italy, France, Sardinia, Sicily (+2 more), Corsica, Spain
INSIDE
$2,677
OCEANVIEW
$3,033
BALCONY
$3,568
SUITE
$7,399
From 2,677
View Trip
10 Day Italy to France & Spain with Virgin Voyages
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 07 October 2025
Countries Visited: Italy, Sardinia, Corsica, France (+1 more), Spain
INSIDE
$2,460
OCEANVIEW
$2,551
BALCONY
$2,800
SUITE
$6,296
From 2,460
View Trip
8 Day Mediterranean Tapestry with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 15 November 2024
Countries Visited: Italy, France, Spain
Explore More OfferExclusive Deal
INSIDE
-
OCEANVIEW
$3,993
BALCONY
$5,006
SUITE
$5,927
Save 7,577
From 3,993
View Trip
11 Day Italy, Greece, & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Venice to Barcelona
Ships: Norwegian Breakaway, Norwegian Escape
Departures: May 2024 to Oct 2025
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), France, Spain
INSIDE
$1,616
OCEANVIEW
$3,673
BALCONY
$4,621
SUITE
$5,048
From 1,616
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 20 July 2024
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$5,447
OCEANVIEW
$5,902
BALCONY
$7,358
SUITE
$8,768
From 5,447
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Livorno to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 23 June 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$552
SUITE
-
From 552
View Trip
29 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

29 Days (28 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 September 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Spain, Turkey
INSIDE
$5,741
OCEANVIEW
$6,305
BALCONY
$7,058
SUITE
$15,334
From 5,741
View Trip
8 Day Western Mediterranean with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 10 August 2026
Countries Visited: Italy, Spain, France
INSIDE
$1,684
OCEANVIEW
$1,882
BALCONY
$2,328
SUITE
$4,654
From 1,684
View Trip
17 Day Civitavecchia to Barcelona with Silversea
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 22 July 2025
Countries Visited: Italy, Sicily, Monaco, France (+1 more), Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,513
From 18,513
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 03 August 2026
Countries Visited: Italy, Croatia, Malta, Spain (+1 more), France
INSIDE
$3,320
OCEANVIEW
$3,667
BALCONY
$4,162
SUITE
$8,914
From 3,320
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Rome to Valencia
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 19 May 2024
Countries Visited: Italy, Sicily, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$805
SUITE
-
From 805
View Trip
13 Day Sunset Over Tuscany with Regent Seven Seas
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 22 October 2025
Countries Visited: Italy, Malta, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,202
SUITE
$16,271
Save 6,328
From 14,202
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Venice to Barcelona
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departures: Jun 2024 to Jul 2024
Countries Visited: Italy, Sicily, France, Spain
Exclusive Deal
INSIDE
$1,525
OCEANVIEW
$2,289
BALCONY
$2,436
SUITE
$3,866
Save 909
From 1,525
View Trip
22 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 September 2025
Countries Visited: Italy, Croatia, Malta, Spain (+2 more), Greece, Turkey
INSIDE
$3,956
OCEANVIEW
$4,422
BALCONY
$5,085
SUITE
$10,629
From 3,956
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$433
OCEANVIEW
$512
BALCONY
$621
SUITE
$1,017
From 433
View Trip
Results: 31-60 of 129

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