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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 230 departures available from sixteen of the world's leading cruise lines.
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129 Cruises (230 Cruise Departures)
13 Day Greek Isles, Italy & Turkey with Celebrity Cruises
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 14 October 2024
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive DealExclusive Offer
INSIDE
$3,030
OCEANVIEW
$3,665
BALCONY
$4,791
SUITE
$11,175
Save 3,886
From 2,989
View Trip
22 Day Greece, Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 26 May 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Corsica, Spain
INSIDE
$4,145
OCEANVIEW
$4,521
BALCONY
$5,174
SUITE
$11,005
From 4,145
View Trip
7 Day A Journey From Italian Piazzas To Tunisian Souks with Explora Journeys
Cruise

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 30 September 2024
Countries Visited: Italy, Sicily, Tunisia, Spain (+3 more), Gibraltar, Portugal, Morocco
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$6,866
SUITE
$7,945
From 5,420
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2024 to Sep 2024
Countries Visited: Italy, France, Spain
INSIDE
$1,882
OCEANVIEW
$2,179
BALCONY
$2,377
SUITE
$4,753
From 1,882
View Trip
8 Day Spanish & Italian Hot Spots with Virgin Voyages
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 06 July 2025
Countries Visited: Italy, Sicily, Corsica, Spain
Up to 80% Off Second Sailor + Free Upgrade
INSIDE
$2,324
OCEANVIEW
$2,733
BALCONY
$3,027
SUITE
$6,863
From 2,324
View Trip
15 Day Greece, Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 August 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+2 more), France, Spain
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,568
SUITE
$7,667
From 2,766
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 10 August 2024
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$6,313
OCEANVIEW
$7,090
BALCONY
$9,436
SUITE
-
From 6,313
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 06 July 2026
Countries Visited: Italy, Croatia, Malta, France (+2 more), Corsica, Spain
INSIDE
$4,610
OCEANVIEW
$4,956
BALCONY
$5,946
SUITE
$12,381
From 4,610
View Trip
8 Day Central Mediterranean with Cunard
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Croatia, Malta, Spain
INSIDE
$1,516
OCEANVIEW
$1,694
BALCONY
$2,001
SUITE
$4,189
From 1,516
View Trip
16 Day Civitavecchia to Barcelona with Silversea
Cruise

16 Days (15 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 30 May 2025
Countries Visited: Italy, Sicily, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$17,919
From 17,919
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Aug 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$3,619
OCEANVIEW
$4,826
BALCONY
$5,282
SUITE
$6,430
From 3,619
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 27 September 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
INSIDE
$4,050
OCEANVIEW
$5,054
BALCONY
$6,430
SUITE
$7,499
From 4,050
View Trip
6 Day Mediterranean with MSC Cruises
Cruise

6 Days (5 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 28 October 2024
Countries Visited: Italy, Sicily, Tunisia, Spain
Exclusive Deal
INSIDE
$764
OCEANVIEW
$942
BALCONY
$1,081
SUITE
-
From 764
View Trip
22 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 September 2025
Countries Visited: Italy, Croatia, Malta, Spain (+2 more), Greece, Turkey
INSIDE
$3,956
OCEANVIEW
$4,422
BALCONY
$5,085
SUITE
$10,629
From 3,956
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jul 2024 to Aug 2024
Countries Visited: Italy, Croatia, Malta, France (+1 more), Spain
INSIDE
$2,895
OCEANVIEW
$3,192
BALCONY
$4,380
SUITE
$7,686
From 2,895
View Trip
8 Day Mediterranean Marvels & Matches: Barcelona Open with Seabourn
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Venture
Departure: 13 April 2025
Countries Visited: Italy, France, Spain
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$7,749
SUITE
$18,436
From 7,749
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
INSIDE
$2,677
OCEANVIEW
$3,033
BALCONY
$3,390
SUITE
$7,399
From 2,677
View Trip
12 Day Rome to Barcelona with Silversea
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 12 November 2024
Countries Visited: Italy, Spain, Tunisia, Malta
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$11,187
From 11,187
View Trip
12 Day Best Of The Med Voyage with Azamara Cruises
Cruise

12 Days (11 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Pursuit
Departure: 12 May 2024
Countries Visited: Italy, Croatia, Montenegro, France (+1 more), Spain
Circle Club Voyage
INSIDE
$4,044
OCEANVIEW
$5,375
BALCONY
$8,111
SUITE
-
From 4,044
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 18 June 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$680
SUITE
-
From 680
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departures: Jul 2024 to Nov 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
The Sail Away EventMore Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,913
From 8,424
View Trip
11 Day Mediterranean Hideaways with Oceania Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 26 October 2024
Countries Visited: Italy, Sicily, Malta, Tunisia (+5 more), Sardinia, Corsica, Monaco, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$8,031
SUITE
$17,436
Save 2,069
From 8,031
View Trip
21 Day France & Spanish Treasures with Seabourn
Cruise

21 Days (20 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departures: Jul 2024 to Jun 2025
Countries Visited: Italy, Malta, Tunisia, France (+3 more), Spain, Gibraltar, Morocco
The Sail Away EventMore Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$14,571
SUITE
$30,312
From 14,571
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
INSIDE
-
OCEANVIEW
-
BALCONY
$6,534
SUITE
$7,945
From 5,197
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, France, Spain
Exclusive DealExclusive Offer
INSIDE
$2,386
OCEANVIEW
$2,846
BALCONY
$3,077
SUITE
$8,100
Save 3,494
From 2,386
View Trip
15 Day Charming Coasts & Treasures with Regent Seven Seas
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 25 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Corsica, Monaco, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$17,161
SUITE
$19,002
Save 6,959
From 17,161
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 13 July 2026
Countries Visited: Italy, France, Corsica, Spain
INSIDE
$3,172
OCEANVIEW
$3,518
BALCONY
$3,964
SUITE
$8,518
From 3,172
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,745
From 8,424
View Trip
12 Day A Journey From Rome To Barcelona with Explora Journeys
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 April 2025
Countries Visited: Italy, Spain, Morocco, Gibraltar
INSIDE
-
OCEANVIEW
-
BALCONY
$10,251
SUITE
$12,509
From 8,093
View Trip
21 Day Elegance In The Mediterranean with Regent Seven Seas
Cruise

21 Days (20 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 28 April 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+4 more), Malta, Sicily, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$24,773
SUITE
$26,694
Save 9,127
From 24,773
View Trip
Results: 91-120 of 129

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