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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? May is the most popular month to cruise between Spain and Italy and there are 203 departures available from sixteen of the world's leading cruise lines.
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107 Cruises (203 Cruise Departures)
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+1 more), France
INSIDE
$2,974
OCEANVIEW
$3,320
BALCONY
$3,766
SUITE
$7,924
From 2,974
View Trip
21 Day Spain, Morocco & Mediterranean Overture with Seabourn
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Gibraltar, Morocco (+4 more), Monaco, Italy, Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$15,418
SUITE
$28,714
From 15,418
View Trip
5 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

5 Days (4 Nights) Barcelona to Rome
Ship: Norwegian Escape
Departures: May 2024 to Sep 2024
Countries Visited: Spain, France, Italy
INSIDE
$1,515
OCEANVIEW
$1,760
BALCONY
$1,990
SUITE
$2,066
From 1,515
View Trip
8 Day A Journey Of Riviera Reveries And Italian Icons with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 26 August 2024
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,994
SUITE
$9,261
From 7,153
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 12 July 2024
Countries Visited: Spain, France, Monaco, Italy (+2 more), Corsica, Sardinia
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$11,394
SUITE
-
From 11,394
View Trip
21 Day France & Spanish Treasures with Seabourn
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 October 2024
Countries Visited: Spain, France, Tunisia, Italy (+2 more), Sicily, Malta
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$19,126
SUITE
-
From 19,126
View Trip
8 Day A Journey From Tarragona To Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 September 2024
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$7,994
SUITE
$9,261
From 6,311
View Trip
8 Day Central Mediterranean with Cunard
Cruise

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia
INSIDE
$1,516
OCEANVIEW
$1,694
BALCONY
$1,962
SUITE
$4,189
From 1,516
View Trip
11 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Escape
Departure: 11 August 2024
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
INSIDE
$3,104
OCEANVIEW
$4,098
BALCONY
$4,022
SUITE
$4,480
From 3,104
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Countries Visited: Spain, Sardinia, Sicily, Italy (+3 more), Greece, Montenegro, Croatia
INSIDE
$3,172
OCEANVIEW
$3,518
BALCONY
$4,112
SUITE
$8,518
From 3,172
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise

12 Days (11 Nights) Santa Cruz de Tenerife to Venice
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 23 March 2025
Countries Visited: Spain, Morocco, Sicily, Greece (+2 more), Italy, Croatia
Save And Sail Offer
INSIDE
$1,567
OCEANVIEW
$1,914
BALCONY
$2,844
SUITE
$4,280
From 1,567
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sicily
INSIDE
$2,726
OCEANVIEW
$2,974
BALCONY
$3,370
SUITE
$7,231
From 2,726
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 24 March 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$330
OCEANVIEW
$419
BALCONY
$498
SUITE
$914
From 330
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Aug 2025
Countries Visited: Spain, France, Italy
INSIDE
-
OCEANVIEW
-
BALCONY
$6,534
SUITE
$7,945
From 5,940
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 October 2024
Countries Visited: Spain, Italy
Best Deal Offer
INSIDE
$362
OCEANVIEW
$490
BALCONY
$540
SUITE
-
From 362
View Trip
17 Day Barcelona to Civitavecchia with Silversea
Cruise

17 Days (16 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 06 July 2025
Countries Visited: Spain, France, Monaco, Italy (+1 more), Sicily
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,513
From 18,513
View Trip
8 Day Italy And Adriatic with Cunard
Cruise

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Countries Visited: Spain, Italy, Sicily, Greece (+1 more), Montenegro
INSIDE
$1,783
OCEANVIEW
$1,981
BALCONY
$2,179
SUITE
$4,951
From 1,783
View Trip
9 Day A Journey To Elegant Enclaves On Old European Shores with Explora Journeys
Cruise

9 Days (8 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 11 August 2024
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,801
SUITE
$11,979
From 8,331
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 06 November 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$384
OCEANVIEW
$463
BALCONY
$542
SUITE
$958
From 384
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia (+2 more), Montenegro, Greece
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,657
SUITE
$7,667
From 2,766
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$614
BALCONY
$742
SUITE
$1,445
From 614
View Trip
11 Day Europe with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Dawn
Departure: 07 October 2024
Countries Visited: Spain, France, Italy, Sicily (+3 more), Greece, Montenegro, Croatia
INSIDE
$2,924
OCEANVIEW
$3,275
BALCONY
$4,377
SUITE
$4,530
From 2,924
View Trip
6 Day France & Italy Cruise with Royal Caribbean
Cruise

6 Days (5 Nights) Barcelona to Ravenna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 12 May 2025
Countries Visited: Spain, Corsica, Italy, Sicily
Exclusive Deal
INSIDE
$1,533
OCEANVIEW
$1,847
BALCONY
$2,075
SUITE
$3,443
Save 581
From 1,327
View Trip
8 Day France And Italy with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Aug 2024 to Sep 2024
Countries Visited: Spain, Sardinia, Corsica, Sicily (+1 more), Italy
INSIDE
$2,130
OCEANVIEW
$2,278
BALCONY
$2,377
SUITE
$4,120
From 2,130
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 05 August 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,533
OCEANVIEW
$2,568
BALCONY
$2,946
SUITE
$4,807
Save 858
From 1,887
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departures: Sep 2024 to Oct 2024
Countries Visited: Spain, France, Corsica, Italy (+2 more), Malta, Sicily
Exclusive DealExclusive Offer
INSIDE
$2,527
OCEANVIEW
$3,727
BALCONY
$3,784
SUITE
$9,450
Save 3,530
From 2,527
View Trip
11 Day Grand Mediterranean with Princess
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 11 October 2025
Countries Visited: Spain, France, Italy, Montenegro (+1 more), Greece
INSIDE
$2,713
OCEANVIEW
$3,317
BALCONY
$4,238
SUITE
$5,089
From 2,713
View Trip
11 Day Italian Riviera & France with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 08 June 2024
Countries Visited: Spain, Corsica, Italy, France (+3 more), Sardinia, Malta, Sicily
Exclusive DealExclusive Offer
INSIDE
$2,396
OCEANVIEW
$6,218
BALCONY
$3,590
SUITE
$10,532
Save 3,017
From 2,077
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Monaco, Italy (+2 more), Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,913
From 8,424
View Trip
13 Day Best Of The Med Voyage with Azamara Cruises
Cruise

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Pursuit
Departure: 13 July 2024
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
Circle Club Voyage
INSIDE
-
OCEANVIEW
$4,448
BALCONY
$4,464
SUITE
$7,300
From 4,445
View Trip
Results: 31-60 of 107

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