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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 233 departures available from sixteen of the world's leading cruise lines.
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128 Cruises (233 Cruise Departures)
13 Day Mediterranean Odyssey with Viking Cruises
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Saturn, Viking Sea (+3 more), Viking Sky, Viking Star, Viking Vesta
Departures: May 2024 to Aug 2026
Countries Visited: Italy, Croatia, Greece, Monaco (+2 more), France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$6,925
SUITE
$10,390
Save 1,210
From 6,925
View Trip
11 Day Grand Mediterranean with Princess
Cruise
 (3)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Majestic Princess
Departure: 30 June 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
INSIDE
$2,934
OCEANVIEW
-
BALCONY
$4,237
SUITE
$5,151
From 2,934
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+8 more), Viking Neptune, Viking Saturn, Viking Sea, Viking Sky, Viking Star, Viking Vela, Viking Venus, Viking Vesta
Departures: Jul 2024 to Sep 2026
Countries Visited: Italy, Monaco, France, Spain
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$4,450
SUITE
$6,925
Save 1,125
From 4,450
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11 Day Renaissance Triumphs with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 04 November 2024
Countries Visited: Italy, Sicily, Malta, France (+1 more), Spain
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$6,398
SUITE
$9,091
Save 2,052
From 6,398
View Trip
12 Day Rivieras & Yacht Havens Voyage with Azamara Cruises
Cruise
 (1)

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 26 August 2025
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$4,368
OCEANVIEW
$4,829
BALCONY
$5,519
SUITE
$7,588
From 4,368
View Trip
11 Day Mediterranean Melange with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 29 October 2025
Countries Visited: Italy, Sicily, Sardinia, Corsica (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,419
OCEANVIEW
$4,874
BALCONY
$7,320
SUITE
$9,854
Save 2,031
From 4,419
View Trip
12 Day Around Italy's Boot: Cote D'azur with Holland America
Cruise
 (1)

12 Days (11 Nights) Venice to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 30 August 2025
Countries Visited: Italy, Montenegro, Greece, Sicily (+2 more), France, Spain
Have It All Offer
INSIDE
$3,793
OCEANVIEW
$3,991
BALCONY
$4,981
SUITE
$6,862
From 3,793
View Trip
11 Day Autumnal Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 18 October 2025
Countries Visited: Italy, Sicily, Malta, Tunisia (+3 more), Monaco, France, Spain
Exclusive Deal
INSIDE
$4,726
OCEANVIEW
$5,181
BALCONY
$7,626
SUITE
$10,309
Save 2,034
From 4,726
View Trip
10 Day Cities Of The Western Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 31 October 2024
Countries Visited: Italy, Monaco, France, Spain
INSIDE
$2,033
OCEANVIEW
$2,205
BALCONY
$4,219
SUITE
$5,512
From 2,033
View Trip
11 Day Adriatic & Med Gateways Voyage with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 30 May 2024
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+2 more), Monaco, Spain
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$9,645
From 9,645
View Trip
19 Day Malta & Mediterranean Romance with Holland America
Cruise
 (1)

19 Days (18 Nights) Rome to Barcelona
Cruise Line: Holland America
Ship: Oosterdam
Departure: 01 September 2024
Countries Visited: Italy, Sicily, Malta, Greece (+5 more), Turkey, Albania, Corsica, France, Spain
Have It All Offer
INSIDE
$5,178
OCEANVIEW
$5,822
BALCONY
$6,802
SUITE
$9,594
From 5,178
View Trip
10 Day Islands Of The Med Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 18 October 2024
Countries Visited: Italy, Corsica, Sardinia, Spain
INSIDE
-
OCEANVIEW
$2,869
BALCONY
$4,571
SUITE
$6,490
From 2,869
View Trip
11 Day Adriatic & Med Gateways Voyage with Azamara Cruises
Cruise
 (1)

11 Days (10 Nights) Venice to Barcelona
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 01 June 2026
Countries Visited: Italy, Slovenia, Croatia, Montenegro (+2 more), Monaco, Spain
INSIDE
$5,325
OCEANVIEW
$5,899
BALCONY
$6,819
SUITE
$9,348
From 5,325
View Trip
13 Day Roman Holiday To Toulon & Beyond with Regent Seven Seas
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Voyager
Departure: 14 November 2025
Countries Visited: Italy, France, Spain, Corsica (+1 more), Sardinia
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$13,468
SUITE
$15,824
Save 6,472
From 13,468
View Trip
13 Day Greek Isles, Italy & Turkey with Celebrity Cruises
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 14 October 2024
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Offer
INSIDE
$2,989
OCEANVIEW
$3,581
BALCONY
$4,939
SUITE
$11,265
Save 3,776
From 2,989
View Trip
10 Day Italy, France & Spain Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 24 August 2024
Countries Visited: Italy, Sicily, Malta, Corsica (+2 more), France, Spain
Exclusive Offer
INSIDE
$2,277
OCEANVIEW
$2,586
BALCONY
$2,990
SUITE
$7,933
Save 2,878
From 2,277
View Trip
13 Day Mediterranean Tapestry with Oceania Cruises
Cruise

13 Days (12 Nights) Trieste to Barcelona
Cruise Line: Oceania Cruises
Ship: Oceania Vista
Departure: 29 June 2024
Countries Visited: Italy, Croatia, Montenegro, Greece (+5 more), Sicily, Corsica, Monaco, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$10,122
SUITE
-
Save 2,088
From 10,122
View Trip
13 Day Greek Isles, Italy & Turkey with Celebrity Cruises
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 23 September 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive Offer
INSIDE
$3,694
OCEANVIEW
-
BALCONY
-
SUITE
$11,659
Save 4,230
From 3,694
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Genoa to Alicante
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 April 2025
Countries Visited: Italy, France, Spain, Portugal
Early Booking Offer
INSIDE
$1,702
OCEANVIEW
$1,831
BALCONY
$2,098
SUITE
-
From 1,702
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Aug 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$3,648
OCEANVIEW
$4,628
BALCONY
$5,202
SUITE
$6,282
From 3,648
View Trip
22 Day Italy, Spain And Adriatic with Cunard
Cruise

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 June 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Spain, France
INSIDE
$4,610
OCEANVIEW
$4,956
BALCONY
$5,748
SUITE
$12,183
From 4,610
View Trip
21 Day Elegance In The Mediterranean with Regent Seven Seas
Cruise

21 Days (20 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 28 April 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+4 more), Malta, Sicily, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$24,773
SUITE
$26,694
Save 9,127
From 24,773
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 20 July 2026
Countries Visited: Italy, France, Corsica, Spain
INSIDE
$1,684
OCEANVIEW
$1,882
BALCONY
$2,080
SUITE
$4,654
From 1,684
View Trip
8 Day Central Mediterranean with Cunard
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Croatia, Malta, Spain
INSIDE
$1,516
OCEANVIEW
$1,694
BALCONY
$2,001
SUITE
$4,189
From 1,516
View Trip
9 Day Italy, France & Spain Cruise with Celebrity Cruises
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 06 June 2025
Countries Visited: Italy, France, Spain
Exclusive Offer
INSIDE
$2,290
OCEANVIEW
$2,567
BALCONY
$3,019
SUITE
$8,173
Save 3,015
From 2,290
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 13 July 2026
Countries Visited: Italy, France, Corsica, Spain
INSIDE
$3,172
OCEANVIEW
$3,518
BALCONY
$3,964
SUITE
$8,518
From 3,172
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Moon
Departure: 06 August 2024
Countries Visited: France, Italy, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$8,860
BALCONY
$10,345
SUITE
$27,621
From 8,860
View Trip
12 Day A Journey From Rome To Barcelona with Explora Journeys
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 23 April 2025
Countries Visited: Italy, Spain, Morocco, Gibraltar
Exclusive DealThe Total Luxury Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,093
SUITE
$9,875
From 10,098
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departures: Jul 2024 to Nov 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
Earlybird SavingExclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,909
SUITE
$16,145
From 9,909
View Trip
10 Day Italy to France & Spain with Virgin Voyages
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 07 October 2025
Countries Visited: Italy, Sardinia, Corsica, France (+1 more), Spain
INSIDE
$2,465
OCEANVIEW
$2,555
BALCONY
$2,804
SUITE
$6,305
From 2,465
View Trip
Results: 1-30 of 128

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