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Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 225 departures available from sixteen of the world's leading cruise lines.
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125 Cruises (225 Cruise Departures)
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Moon
Departure: 06 August 2024
Countries Visited: France, Italy, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$8,860
BALCONY
$10,345
SUITE
$32,175
From 8,860
View Trip
17 Day Civitavecchia to Barcelona with Silversea
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 22 July 2025
Countries Visited: Italy, Sicily, Monaco, France (+1 more), Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,513
From 18,513
View Trip
8 Day A Journey From Civitavecchia To Barcelona with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 29 September 2025
Countries Visited: Italy, Sicily, Tunisia, Sardinia (+1 more), Spain
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
22 Day Italy, Spain And Adriatic with Cunard
Cruise

22 Days (21 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 01 June 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Spain, France
INSIDE
$4,610
OCEANVIEW
$4,956
BALCONY
$5,748
SUITE
$12,183
From 4,610
View Trip
12 Day Grand Mediterranean with Princess
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 21 October 2025
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
INSIDE
$3,319
OCEANVIEW
$4,240
BALCONY
$5,002
SUITE
$5,319
From 3,319
View Trip
4 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

4 Days (3 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ships: Allure of the Seas, Oasis of the Seas
Departures: Sep 2024 to Oct 2025
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$1,335
OCEANVIEW
$1,486
BALCONY
$1,596
SUITE
$2,343
Save 698
From 1,142
View Trip
11 Day Greek Isles & Turkey with Celebrity Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2024 to Sep 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive DealExclusive Offer
INSIDE
$3,072
OCEANVIEW
$3,100
BALCONY
$3,741
SUITE
$7,886
Save 3,684
From 2,974
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2024 to Sep 2024
Countries Visited: Italy, France, Spain
INSIDE
$1,882
OCEANVIEW
$2,179
BALCONY
$2,377
SUITE
$4,753
From 1,882
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Rome to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 16 April 2025
Countries Visited: Italy, Spain
Exclusive Deal
INSIDE
$433
OCEANVIEW
$512
BALCONY
$621
SUITE
$1,017
From 433
View Trip
8 Day Central Mediterranean with Cunard
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Croatia, Malta, Spain
INSIDE
$1,516
OCEANVIEW
$1,694
BALCONY
$2,001
SUITE
$4,189
From 1,516
View Trip
18 Day Mediterranean Majesty with Regent Seven Seas
Cruise

18 Days (17 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 17 October 2024
Countries Visited: Italy, France, Spain, Gibraltar (+2 more), Portugal, Morocco
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$25,145
SUITE
$28,096
Save 5,235
From 25,145
View Trip
21 Day Elegance In The Mediterranean with Regent Seven Seas
Cruise

21 Days (20 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 28 April 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+4 more), Malta, Sicily, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$24,773
SUITE
$48,860
Save 9,127
From 24,773
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 20 July 2026
Countries Visited: Italy, France, Corsica, Spain
INSIDE
$1,684
OCEANVIEW
$1,882
BALCONY
$2,080
SUITE
$4,654
From 1,684
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 04 June 2024
Countries Visited: Italy, France, Spain
Exclusive DealExclusive Offer
INSIDE
$1,959
OCEANVIEW
-
BALCONY
$2,502
SUITE
$7,606
Save 2,766
From 1,875
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departures: Apr 2025 to Aug 2025
Countries Visited: Italy, Greece, Turkey, Montenegro (+2 more), Sicily, Spain
INSIDE
$3,619
OCEANVIEW
$4,826
BALCONY
$5,282
SUITE
$6,430
From 3,619
View Trip
10 Day Wonders Of Spain with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,644
SUITE
$13,465
Save 5,266
From 12,644
View Trip
12 Day Greece, Turkey & Italy Cruise with Celebrity Cruises
Cruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 18 June 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive DealExclusive Offer
INSIDE
$3,030
OCEANVIEW
$3,392
BALCONY
$4,907
SUITE
$11,810
Save 3,658
From 2,776
View Trip
29 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

29 Days (28 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 15 September 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+3 more), Malta, Spain, Turkey
INSIDE
$5,741
OCEANVIEW
$6,305
BALCONY
$7,058
SUITE
$15,334
From 5,741
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 06 July 2026
Countries Visited: Italy, Croatia, Malta, France (+2 more), Corsica, Spain
INSIDE
$4,610
OCEANVIEW
$4,956
BALCONY
$5,946
SUITE
$12,381
From 4,610
View Trip
8 Day Spain And Adriatic with Cunard
Cruise

8 Days (7 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 23 September 2024
Countries Visited: Italy, Croatia, Malta, Spain
INSIDE
$1,882
OCEANVIEW
$2,179
BALCONY
$2,674
SUITE
$6,436
From 1,882
View Trip
31 Day Riviera, Mediterranean & Tyrrhenian Treasures with Seabourn
Cruise

31 Days (30 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+5 more), Spain, Sardinia, Monaco, Sicily, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$22,411
SUITE
$42,860
From 22,411
View Trip
13 Day Sunset Over Tuscany with Regent Seven Seas
Cruise

13 Days (12 Nights) Venice to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Mariner
Departure: 22 October 2025
Countries Visited: Italy, Malta, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$14,202
SUITE
$16,271
Save 6,328
From 14,202
View Trip
2 Day Mediterranean with MSC Cruises
Cruise

2 Days (1 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Poesia
Departure: 11 October 2024
Countries Visited: Italy, Spain
Early Booking With Easy Drink Packages
INSIDE
$181
OCEANVIEW
$210
BALCONY
$270
SUITE
$537
From 181
View Trip
8 Day Mediterranean Tapestry with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 15 November 2024
Countries Visited: Italy, France, Spain
Explore More OfferExclusive Deal
INSIDE
-
OCEANVIEW
$3,993
BALCONY
$5,006
SUITE
$5,927
Save 7,577
From 3,993
View Trip
10 Day Italy to France & Spain with Virgin Voyages
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 07 October 2025
Countries Visited: Italy, Sardinia, Corsica, France (+1 more), Spain
INSIDE
$2,460
OCEANVIEW
$2,551
BALCONY
$2,800
SUITE
$6,296
From 2,460
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
INSIDE
$3,320
OCEANVIEW
$3,667
BALCONY
$4,162
SUITE
$8,914
From 3,320
View Trip
15 Day Greece, Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 25 August 2025
Countries Visited: Italy, Croatia, Montenegro, Greece (+2 more), France, Spain
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,568
SUITE
$7,667
From 2,766
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Moon
Departure: 01 October 2024
Countries Visited: France, Italy, Monaco, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
$12,078
BALCONY
$13,860
SUITE
$33,759
From 12,078
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Ravenna to Barcelona
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 15 September 2025
Countries Visited: Italy, Sicily, France, Spain
Exclusive Deal
INSIDE
$1,632
OCEANVIEW
$2,281
BALCONY
$2,694
SUITE
$3,414
Save 651
From 1,464
View Trip
12 Day Cultures of the Mediterranean with Emerald Cruises
New ReleaseCruise

12 Days (11 Nights) Rome to Barcelona
Cruise Line: Emerald Cruises
Ship: Emerald Sakara
Departure: 29 October 2024
Countries Visited: Italy, Sicily, Malta, Tunisia (+2 more), Sardinia, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$12,568
Save 2,627
From 12,568
View Trip
Results: 91-120 of 125

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