Home > Cruises > Europe Cruises > Mediterranean Cruises > Cruises from Italy to Spain

Cruises from Italy to Spain

Are you looking for a cruise from Italy to Spain? September is the most popular month to cruise between Italy and Spain and there are 223 departures available from sixteen of the world's leading cruise lines.
Filter Results
Departures
Show More...
Duration
2 Days
31 Days
Start & End Cities
Ship Size
Ship Features
Operators
Show More...
Price
$100pp
$38,195pp
Countries
Show More...
Filter Results
125 Cruises (223 Cruise Departures)
10 Day Wonders Of Spain with Regent Seven Seas
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Grandeur
Departure: 09 May 2025
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$12,644
SUITE
$13,465
Save 5,266
From 12,644
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Genoa to Barcelona
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 16 November 2024
Countries Visited: Italy, France, Spain
Exclusive Deal
INSIDE
$234
OCEANVIEW
$303
BALCONY
$373
SUITE
$699
From 234
View Trip
31 Day Riviera, Mediterranean & Tyrrhenian Treasures with Seabourn
Cruise

31 Days (30 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+5 more), Spain, Sardinia, Monaco, Sicily, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$22,411
SUITE
$42,860
From 22,411
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2025 to Sep 2025
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
INSIDE
$2,677
OCEANVIEW
$3,033
BALCONY
$3,390
SUITE
$7,399
From 2,677
View Trip
8 Day Mediterranean Tapestry with Regent Seven Seas
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Regent Seven Seas
Ship: Seven Seas Navigator
Departure: 15 November 2024
Countries Visited: Italy, France, Spain
Explore More OfferExclusive Deal
INSIDE
-
OCEANVIEW
$3,993
BALCONY
$5,006
SUITE
$5,927
Save 7,577
From 3,993
View Trip
11 Day Italy, Greece, & France: Mediterranean Jewels with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Venice to Barcelona
Ships: Norwegian Breakaway, Norwegian Escape
Departures: May 2024 to Oct 2025
Countries Visited: Italy, Croatia, Greece, Sicily (+2 more), France, Spain
Exclusive Solo Offer
INSIDE
$1,616
OCEANVIEW
$3,779
BALCONY
$4,696
SUITE
$5,079
From 1,616
View Trip
11 Day Greek Isles & Turkey with Celebrity Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: Jun 2024 to Sep 2024
Countries Visited: Italy, Greece, Turkey, Malta (+1 more), Spain
Exclusive Offer
INSIDE
$3,146
OCEANVIEW
$3,175
BALCONY
$3,628
SUITE
$7,977
Save 3,723
From 3,146
View Trip
11 Day Greek Isles & Turkey with Celebrity Cruises
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 17 August 2024
Countries Visited: Italy, Greece, Turkey, Sicily (+1 more), Spain
Exclusive Offer
INSIDE
$2,411
OCEANVIEW
-
BALCONY
$2,840
SUITE
$7,201
Save 3,177
From 2,411
View Trip
9 Day Civitavecchia to Barcelona with Silversea
Cruise

9 Days (8 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 23 September 2025
Countries Visited: Italy, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$12,078
From 12,078
View Trip
10 Day Ultimate Italy, France & Spain Cruise with Royal Caribbean
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Royal Caribbean
Ship: Serenade of the Seas
Departure: 01 July 2024
Countries Visited: Italy, Corsica, France, Spain
Exclusive Deal
INSIDE
$5,282
OCEANVIEW
$4,008
BALCONY
$6,546
SUITE
-
Save 1,652
From 3,675
View Trip
8 Day France, Italy & Greece Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Ravenna to Barcelona
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 23 June 2025
Countries Visited: Italy, Croatia, Greece, France (+1 more), Spain
Exclusive Deal
INSIDE
$2,024
OCEANVIEW
$2,645
BALCONY
$3,160
SUITE
$3,710
Save 806
From 1,808
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 03 August 2026
Countries Visited: Italy, Croatia, Malta, Spain (+1 more), France
INSIDE
$3,320
OCEANVIEW
$3,667
BALCONY
$4,162
SUITE
$8,914
From 3,320
View Trip
16 Day Civitavecchia to Barcelona with Silversea
Cruise

16 Days (15 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 30 May 2025
Countries Visited: Italy, Sicily, France, Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$17,919
From 17,919
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 30 October 2024
Countries Visited: Italy, Sardinia, Corsica, Monaco (+2 more), France, Spain
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$10,305
SUITE
$16,146
From 10,305
View Trip
8 Day Mediterranean Marvels & Matches: Barcelona Open with Seabourn
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Venture
Departure: 13 April 2025
Countries Visited: Italy, France, Spain
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$7,749
SUITE
$18,436
From 7,749
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2025 to Oct 2025
Countries Visited: Italy, France, Spain
Exclusive Offer
INSIDE
$2,171
OCEANVIEW
$2,823
BALCONY
$2,932
SUITE
$8,050
Save 3,532
From 2,171
View Trip
8 Day A Journey Of Limoncello Days And Catalonia Nights with Explora Journeys
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 02 September 2024
Countries Visited: Italy, Sicily, Tunisia, Spain
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,613
SUITE
$6,826
From 5,613
View Trip
10 Day Italian Riviera & France Cruise with Celebrity Cruises
Cruise

10 Days (9 Nights) Rome to Barcelona
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 05 August 2025
Countries Visited: Italy, France, Spain
Exclusive Offer
INSIDE
$2,727
OCEANVIEW
$3,288
BALCONY
$3,391
SUITE
$8,496
Save 3,525
From 2,727
View Trip
11 Day Rome to Barcelona with Silversea
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Moon
Departure: 06 August 2024
Countries Visited: France, Italy, Spain
Mutiple Deals Available
INSIDE
-
OCEANVIEW
$8,860
BALCONY
$10,345
SUITE
$32,175
From 8,860
View Trip
17 Day Civitavecchia to Barcelona with Silversea
Cruise

17 Days (16 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Ray
Departure: 15 September 2025
Countries Visited: Italy, Sicily, Tunisia, France (+1 more), Spain
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,909
From 18,909
View Trip
9 Day Italy, France & Croatia Cruise with Royal Caribbean
Cruise

9 Days (8 Nights) Ravenna to Barcelona
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 13 September 2025
Countries Visited: Italy, Croatia, France, Spain
Exclusive Deal
INSIDE
$2,174
OCEANVIEW
$3,008
BALCONY
$3,400
SUITE
$4,536
Save 855
From 1,897
View Trip
7 Day A Journey From Italian Piazzas To Tunisian Souks with Explora Journeys
Cruise

7 Days (6 Nights) Rome to Barcelona
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 30 September 2024
Countries Visited: Italy, Sicily, Tunisia, Spain (+3 more), Gibraltar, Portugal, Morocco
Exclusive DealUnique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,420
SUITE
$6,272
From 5,420
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Genoa to Alicante
Cruise Line: MSC Cruises
Ship: MSC Musica
Departure: 26 April 2025
Countries Visited: Italy, France, Spain, Portugal
Early Booking Offer
INSIDE
$1,702
OCEANVIEW
$1,831
BALCONY
$2,098
SUITE
-
From 1,702
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 24 August 2026
Countries Visited: Italy, Greece, Montenegro, Croatia (+2 more), Malta, Spain
INSIDE
$3,320
OCEANVIEW
$3,667
BALCONY
$4,162
SUITE
$8,914
From 3,320
View Trip
11 Day Riviera & Mediterranean Jewels with Seabourn
Cruise

11 Days (10 Nights) Rome to Barcelona
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 August 2025
Countries Visited: Italy, Malta, Tunisia, France (+1 more), Spain
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,745
From 8,424
View Trip
13 Day Rome to Barcelona with Silversea
Cruise

13 Days (12 Nights) Rome to Barcelona
Cruise Line: Silversea
Ship: Silver Spirit
Departure: 16 May 2024
Countries Visited: Italy, Monaco, Spain, Malta
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
$19,998
SUITE
-
From 19,998
View Trip
15 Day Mediterranean with Greek Isles, Italy & Turkey with Princess
Cruise

15 Days (14 Nights) Naples to Barcelona
Cruise Line: Princess
Ship: Sun Princess
Departure: 27 September 2025
Countries Visited: Italy, Sicily, Greece, Turkey (+2 more), Montenegro, Spain
INSIDE
$4,050
OCEANVIEW
$5,054
BALCONY
$6,430
SUITE
$7,499
From 4,050
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 04 August 2025
Countries Visited: Italy, France, Sardinia, Sicily (+2 more), Corsica, Spain
INSIDE
$2,677
OCEANVIEW
$3,033
BALCONY
$3,568
SUITE
$7,399
From 2,677
View Trip
15 Day Adriatic And Western Mediterranean with Cunard
Cruise

15 Days (14 Nights) Trieste to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jul 2024 to Aug 2024
Countries Visited: Italy, Croatia, Malta, France (+1 more), Spain
INSIDE
$2,895
OCEANVIEW
$3,192
BALCONY
$4,380
SUITE
$7,686
From 2,895
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Rome to Barcelona
Cruise Line: Cunard
Ship: Queen Victoria
Departures: Jun 2024 to Sep 2024
Countries Visited: Italy, France, Spain
INSIDE
$1,882
OCEANVIEW
$2,179
BALCONY
$2,377
SUITE
$4,753
From 1,882
View Trip
Results: 61-90 of 125

No Results found. Try changing your search filters.




Cruises found! Scroll up to view

Europe Cruises

All Europe Cruises Adriatic Cruises Aegean Cruises Baltic Cruises Black Sea Cruises Croatia Cruises Med Cruises Greek Islands Cruises UK Cruises Western Europe Cruises

Travel Styles

Festivals & Events Luxury Cruises Short Cruise Breaks

Countries

Corsica Croatia Cyprus Egypt England France Gibraltar Israel Italy Malta Monaco Montenegro Morocco Portugal Sardinia Sicily Spain Tunisia Turkey

Cities

Genoa Naples Ravenna Rome Trieste Venice

Routes

Cruises from Rome to Barcelona Cruises from Trieste to Barcelona Cruises from Venice to Barcelona

Country Routes

Cruises from Italy to Spain

Cruise Lines Exploring The Med

APT Med Cruises Azamara Med Cruises Celebrity Med Cruises Cunard Med Cruises Emerald Med Cruises G Adventures Med Cruises Intrepid Med Cruises MSC Med Cruises NCL Med Cruises Oceania Med Cruises P&O (UK) Med Cruises Princess Med Cruises Regent Seven Seas Med Cruises Royal Caribbean Med Cruises Scenic Med Cruises Silversea Med Cruises Viking Med Cruises Virgin Voyages Med Cruises

© 2010-2024. Global Journeys. You're viewing our site in Australian dollars.

    

About Us | View Your Booking | Terms & Conditions | Site Map | We're Hiring!

Global Journeys Pty Ltd. Member of The Australian Travel Industry Association (AITA) & ATAS Travel Accredited (No. A11351).

Travel Industry Associations