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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? August is the most popular month to cruise between Spain and Italy and there are 222 departures available from sixteen of the world's leading cruise lines.
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116 Cruises (222 Cruise Departures)
8 Day Mediterranean with France & Italy with Princess
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departures: May 2024 to Aug 2025
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
$1,667
OCEANVIEW
$1,815
BALCONY
$1,982
SUITE
$2,667
From 1,667
View Trip
23 Day Jet Set Journey with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 03 August 2024
Countries Visited: Spain, France, Monaco, Italy (+3 more), Sicily, Malta, Greece
Exclusive Deal
INSIDE
-
OCEANVIEW
$13,668
BALCONY
$15,806
SUITE
$22,271
Save 2,112
From 13,668
View Trip
11 Day French, Spanish & Italian Rivieras with Princess
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Island Princess
Departure: 05 August 2024
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
-
OCEANVIEW
$2,919
BALCONY
$3,907
SUITE
$4,065
From 2,919
View Trip
11 Day Marvelous Mediterranean with Oceania Cruises
Cruise
 (2)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 15 May 2024
Countries Visited: Spain, France, Monaco, Italy (+1 more), Corsica
Exclusive Deal
INSIDE
-
OCEANVIEW
$9,774
BALCONY
-
SUITE
-
Save 2,086
From 9,774
View Trip
11 Day Radiant Spain & Italy with Oceania Cruises
Cruise
 (1)

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Riviera
Departure: 03 August 2024
Countries Visited: Spain, France, Monaco, Italy
Exclusive DealSingles Special Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$8,359
SUITE
-
Save 2,071
From 8,359
View Trip
13 Day Best Of The Mediterranean Voyage with Azamara Cruises
Cruise
 (1)

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Onward
Departure: 06 September 2025
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
INSIDE
$6,090
OCEANVIEW
$6,552
BALCONY
$7,241
SUITE
$9,540
From 6,090
View Trip
8 Day Mediterranean Spring with Oceania Cruises
Cruise
 (2)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Sirena
Departure: 06 May 2025
Countries Visited: Spain, France, Monaco, Italy
Exclusive Deal
INSIDE
$4,129
OCEANVIEW
$4,357
BALCONY
$6,109
SUITE
$8,010
Save 2,031
From 4,129
View Trip
21 Day Western Mediterranean & Adriatic Explorer with Princess
Cruise
 (2)

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Island Princess
Departure: 05 August 2024
Countries Visited: Spain, Gibraltar, France, Italy (+5 more), Sicily, Malta, Greece, Montenegro, Croatia
INSIDE
$5,129
OCEANVIEW
$5,340
BALCONY
$6,975
SUITE
$7,643
From 5,129
View Trip
23 Day Scenic Strands & Havens with Oceania Cruises
Cruise
 (1)

23 Days (22 Nights) Malaga to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Nautica
Departure: 07 October 2025
Countries Visited: Spain, Morocco, Portugal, Tunisia (+4 more), Malta, Greece, Sicily, Italy
Exclusive Deal
INSIDE
$9,807
OCEANVIEW
$10,569
BALCONY
$15,608
SUITE
$21,152
Save 2,073
From 9,807
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise
 (3)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Majestic Princess
Departure: 04 March 2025
Countries Visited: Spain, Gibraltar, Corsica, Italy
INSIDE
$1,375
OCEANVIEW
-
BALCONY
$1,560
SUITE
$2,068
From 1,375
View Trip
12 Day Around Italy's Boot: Venice Overnight with Holland America
Cruise
 (1)

12 Days (11 Nights) Barcelona to Venice
Cruise Line: Holland America
Ship: Oosterdam
Departure: 10 September 2025
Countries Visited: Spain, France, Italy, Greece (+2 more), Croatia, Montenegro
Have It All Offer
INSIDE
$3,941
OCEANVIEW
$4,139
BALCONY
$5,278
SUITE
$7,159
From 3,941
View Trip
10 Day France Intensive Voyage with Azamara Cruises
Cruise
 (1)

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Azamara Cruises
Ship: Azamara Quest
Departure: 02 April 2025
Countries Visited: Spain, France, Corsica, Italy
INSIDE
$3,216
OCEANVIEW
$3,678
BALCONY
$4,368
SUITE
$6,091
From 3,216
View Trip
24 Day Mediterranean Tapestry & Empires with Holland America
Cruise
 (1)

24 Days (23 Nights) Barcelona to Venice
Cruise Line: Holland America
Ship: Oosterdam
Departure: 12 June 2024
Countries Visited: Spain, France, Italy, Sicily (+6 more), Malta, Tunisia, Greece, Turkey, Albania, Croatia
Have It All Offer
INSIDE
$7,573
OCEANVIEW
$7,781
BALCONY
$9,533
SUITE
-
From 7,573
View Trip
8 Day Southern France and the Italian Riviera by Sea - with Smithsonian Journeys with Ponant
Cruise
 (1)

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Ponant
Ship: Le Laperouse
Departure: 02 October 2025
Countries Visited: Spain, France, Italy
Exclusive Savings
INSIDE
-
OCEANVIEW
-
BALCONY
$8,301
SUITE
$13,907
Save 159
From 8,301
View Trip
22 Day Greece, Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 July 2025
Countries Visited: Spain, Corsica, France, Italy (+5 more), Sardinia, Sicily, Greece, Montenegro, Croatia
INSIDE
$3,927
OCEANVIEW
$4,283
BALCONY
$4,996
SUITE
$10,698
From 3,927
View Trip
11 Day Europe - Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Dawn
Departure: 07 October 2024
Countries Visited: Spain, France, Italy, Sicily (+4 more), Greece, Montenegro, Slovenia, Croatia
Free At Sea Offer
INSIDE
$3,326
OCEANVIEW
$3,675
BALCONY
$4,769
SUITE
$5,148
From 3,326
View Trip
12 Day Barcelona to Civitavecchia with Virgin Voyages
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 03 November 2024
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
INSIDE
$2,613
OCEANVIEW
$2,613
BALCONY
$2,863
SUITE
$6,785
From 2,613
View Trip
15 Day Italy, Spain And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 17 August 2026
Countries Visited: Spain, Sardinia, Sicily, Italy (+3 more), Greece, Montenegro, Croatia
INSIDE
$3,172
OCEANVIEW
$3,518
BALCONY
$4,112
SUITE
$8,518
From 3,172
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+4 more), Greece, Montenegro, Croatia, Malta
INSIDE
$4,857
OCEANVIEW
$5,253
BALCONY
$6,095
SUITE
$12,876
From 4,857
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 24 March 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$330
OCEANVIEW
$419
BALCONY
$498
SUITE
$914
From 330
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+1 more), France
INSIDE
$2,974
OCEANVIEW
$3,320
BALCONY
$3,766
SUITE
$7,924
From 2,974
View Trip
8 Day Italy And Adriatic with Cunard
Cruise

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Countries Visited: Spain, Italy, Sicily, Greece (+1 more), Montenegro
INSIDE
$1,783
OCEANVIEW
$1,981
BALCONY
$2,179
SUITE
$4,951
From 1,783
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia (+2 more), Montenegro, Greece
INSIDE
$2,766
OCEANVIEW
$3,212
BALCONY
$3,657
SUITE
$7,667
From 2,766
View Trip
8 Day Western Mediterranean with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 September 2025
Countries Visited: Spain, Sardinia, Corsica, Sicily (+1 more), Italy
INSIDE
$1,427
OCEANVIEW
$1,645
BALCONY
$1,873
SUITE
$3,833
From 1,427
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 08 August 2024
Countries Visited: Spain, Italy, France
Exclusive Offer
INSIDE
$1,892
OCEANVIEW
$2,508
BALCONY
$2,858
SUITE
$7,119
Save 2,640
From 1,892
View Trip
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, France, Italy, Corsica (+4 more), Sicily, Greece, Montenegro, Croatia
INSIDE
$3,867
OCEANVIEW
$4,263
BALCONY
$4,857
SUITE
$10,203
From 3,867
View Trip
11 Day Grand Mediterranean with Princess
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 11 October 2025
Countries Visited: Spain, France, Italy, Montenegro (+1 more), Greece
INSIDE
$2,713
OCEANVIEW
$3,317
BALCONY
$4,238
SUITE
$5,089
From 2,713
View Trip
12 Day Barcelona to Rome with Silversea
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 26 April 2025
Countries Visited: Spain, France, Italy, Monaco
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$14,553
From 14,553
View Trip
11 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Escape
Departure: 11 August 2024
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
Free At Sea Offer
INSIDE
$3,081
OCEANVIEW
$3,917
BALCONY
$3,992
SUITE
$4,447
From 3,081
View Trip
13 Day Best Of The Med Voyage with Azamara Cruises
Cruise

13 Days (12 Nights) Barcelona to Venice
Cruise Line: Azamara Cruises
Ship: Azamara Pursuit
Departure: 13 July 2024
Countries Visited: Spain, France, Monaco, Italy (+3 more), Montenegro, Croatia, Slovenia
INSIDE
-
OCEANVIEW
-
BALCONY
$5,187
SUITE
$7,300
From 5,187
View Trip
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