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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? May and September are the most popular months to cruise between Spain and Italy and there are 203 departures available from sixteen of the world's leading cruise lines.
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109 Cruises (203 Cruise Departures)
22 Day Adriatic And Western Mediterranean with Cunard
Cruise

22 Days (21 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 22 June 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+4 more), Greece, Montenegro, Croatia, Malta
INSIDE
$4,857
OCEANVIEW
$5,253
BALCONY
$6,095
SUITE
$12,876
From 4,857
View Trip
5 Day Mediterranean with MSC Cruises
Cruise

5 Days (4 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Seaside
Departure: 29 April 2025
Countries Visited: Spain, Tunisia, Sicily, Italy
Exclusive Deal
INSIDE
$726
OCEANVIEW
$855
BALCONY
$1,004
SUITE
$1,330
From 726
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sicily
INSIDE
$2,726
OCEANVIEW
$2,974
BALCONY
$3,370
SUITE
$7,231
From 2,726
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Barcelona to Genoa
Cruise Line: MSC Cruises
Ship: MSC Orchestra
Departure: 24 March 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$330
OCEANVIEW
$419
BALCONY
$498
SUITE
$914
From 330
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 25 October 2024
Countries Visited: Spain, Italy
Best Deal Offer
INSIDE
$362
OCEANVIEW
-
BALCONY
$540
SUITE
-
From 362
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departures: Jun 2025 to Aug 2025
Countries Visited: Spain, France, Italy
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,940
SUITE
$7,247
From 5,940
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 July 2025
Countries Visited: Spain, Corsica, France, Italy
INSIDE
$1,516
OCEANVIEW
$1,645
BALCONY
$1,912
SUITE
$3,833
From 1,516
View Trip
10 Day Italian Riviera & France with Celebrity Cruises
Cruise

10 Days (9 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 11 July 2024
Countries Visited: Spain, Italy, France
Exclusive DealExclusive Offer
INSIDE
$2,095
OCEANVIEW
$2,204
BALCONY
$2,461
SUITE
$7,015
Save 2,718
From 1,884
View Trip
15 Day Classical Mediterranean with Oceania Cruises
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Oceania Cruises
Ship: Oceania Marina
Departure: 18 May 2024
Countries Visited: Spain, Tunisia, Malta, Sicily (+2 more), Greece, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
-
BALCONY
$9,688
SUITE
$13,322
Save 2,082
From 9,688
View Trip
11 Day Grand Mediterranean with Princess
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Princess
Ship: Sun Princess
Departure: 11 October 2025
Countries Visited: Spain, France, Italy, Montenegro (+1 more), Greece
INSIDE
$2,713
OCEANVIEW
$3,317
BALCONY
$4,238
SUITE
$5,089
From 2,713
View Trip
31 Day Jewels Of Spain, Italy & France with Seabourn
Cruise

31 Days (30 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 11 July 2025
Countries Visited: Spain, Sardinia, France, Italy (+4 more), Monaco, Sicily, Malta, Corsica
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$24,768
SUITE
$43,029
From 24,768
View Trip
11 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 16 May 2025
Countries Visited: Spain, Corsica, Sardinia, Sicily (+2 more), Greece, Italy
Exclusive Deal
INSIDE
$2,976
OCEANVIEW
$4,035
BALCONY
$5,138
SUITE
$11,920
Save 1,197
From 2,691
View Trip
11 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

11 Days (10 Nights) Barcelona to Venice
Ship: Norwegian Escape
Departure: 11 August 2024
Countries Visited: Spain, France, Italy, Sicily (+3 more), Malta, Greece, Croatia
INSIDE
$2,950
OCEANVIEW
$3,792
BALCONY
$3,868
SUITE
$4,327
From 2,950
View Trip
12 Day Barcelona to Civitavecchia with Virgin Voyages
Cruise

12 Days (11 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 03 November 2024
Countries Visited: Spain, France, Italy, Corsica (+1 more), Sardinia
INSIDE
$2,609
OCEANVIEW
$2,609
BALCONY
$2,858
SUITE
-
From 2,609
View Trip
15 Day Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Countries Visited: Spain, Italy, Sicily, Greece (+3 more), Montenegro, Croatia, Malta
INSIDE
$3,320
OCEANVIEW
$3,667
BALCONY
$4,162
SUITE
$8,914
From 3,320
View Trip
8 Day Mediterranean with France & Italy with Princess
Cruise

8 Days (7 Nights) Barcelona to Naples
Cruise Line: Princess
Ship: Sun Princess
Departures: Jun 2025 to Sep 2025
Countries Visited: Spain, Gibraltar, France, Italy
INSIDE
$1,746
OCEANVIEW
$2,132
BALCONY
$2,409
SUITE
$2,825
From 1,746
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 16 June 2025
Countries Visited: Spain, France, Corsica, Italy (+1 more), Sardinia
Unique EscapesPenthouse Dream Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$5,846
SUITE
$7,108
From 5,846
View Trip
8 Day Iconic Western Mediterranean with Viking Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+6 more), Viking Saturn, Viking Sky, Viking Star, Viking Vela, Viking Venus, Viking Vesta
Departures: Jun 2024 to Jul 2026
Countries Visited: Spain, France, Monaco, Italy
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$4,450
SUITE
$6,925
Save 1,279
From 4,450
View Trip
15 Day France, Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 16 June 2025
Countries Visited: Spain, France, Sardinia, Sicily (+4 more), Italy, Greece, Montenegro, Croatia
INSIDE
$2,588
OCEANVIEW
$2,855
BALCONY
$3,568
SUITE
$7,043
From 2,588
View Trip
Results: 91-109 of 109

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Cruises from Spain to Italy

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