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Cruises from Spain to Italy

Are you looking for a cruise from Spain to Italy? May and September are the most popular months to cruise between Spain and Italy and there are 203 departures available from sixteen of the world's leading cruise lines.
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109 Cruises (203 Cruise Departures)
8 Day Spain, France & Italy Cruise with Celebrity Cruises
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 17 August 2024
Countries Visited: Spain, France, Italy
Exclusive DealExclusive Offer
INSIDE
$1,814
OCEANVIEW
$2,056
BALCONY
$2,271
SUITE
$5,586
Save 2,423
From 1,772
View Trip
8 Day Central Mediterranean with Cunard
Cruise

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 18 August 2025
Countries Visited: Spain, Malta, Italy, Croatia
INSIDE
$1,516
OCEANVIEW
$1,694
BALCONY
$1,962
SUITE
$4,189
From 1,516
View Trip
8 Day A Journey From Barcelona To Civitavecchia with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 06 October 2025
Countries Visited: Spain, France, Sardinia, Corsica (+1 more), Italy
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$5,504
SUITE
$6,692
From 5,504
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departures: Jul 2024 to Sep 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,185
OCEANVIEW
$2,649
BALCONY
$2,775
SUITE
$5,182
Save 856
From 1,675
View Trip
12 Day Canary Islands And Madeira with MSC Cruises
Cruise

12 Days (11 Nights) Santa Cruz de Tenerife to Venice
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 23 March 2025
Countries Visited: Spain, Morocco, Sicily, Greece (+2 more), Italy, Croatia
Save And Sail Offer
INSIDE
$1,567
OCEANVIEW
$1,914
BALCONY
$2,844
SUITE
$4,280
From 1,567
View Trip
11 Day Greece, Turkey & Malta with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departure: 25 May 2024
Countries Visited: Spain, Malta, Greece, Turkey (+1 more), Italy
Exclusive Deal
INSIDE
$6,834
OCEANVIEW
-
BALCONY
$4,126
SUITE
-
Save 3,760
From 3,138
View Trip
15 Day Mediterranean & Italian Sojourn with Viking Cruises
Cruise

15 Days (14 Nights) Barcelona to Venice
Cruise Line: Viking Cruises
Ships: Viking Jupiter, Viking Mars (+5 more), Viking Saturn, Viking Sky, Viking Star, Viking Venus, Viking Vesta
Departures: Jan 2025 to Jul 2026
Countries Visited: Spain, France, Monaco, Italy (+2 more), Sicily, Croatia
Discover More Sale
INSIDE
-
OCEANVIEW
-
BALCONY
$9,697
SUITE
$14,350
Save 1,956
From 9,697
View Trip
11 Day Italian Riviera & France with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Ascent
Departure: 08 June 2024
Countries Visited: Spain, Corsica, Italy, France (+3 more), Sardinia, Malta, Sicily
Exclusive Deal
INSIDE
$2,396
OCEANVIEW
$6,277
BALCONY
$4,593
SUITE
$10,532
Save 3,077
From 2,077
View Trip
8 Day Western Mediterranean Cruise with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 05 August 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,342
OCEANVIEW
$2,370
BALCONY
$2,713
SUITE
$4,377
Save 798
From 1,757
View Trip
15 Day Italy, France And Spain with Cunard
Cruise

15 Days (14 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 July 2025
Countries Visited: Spain, Corsica, France, Italy (+2 more), Sardinia, Sicily
INSIDE
$2,855
OCEANVIEW
$3,033
BALCONY
$3,568
SUITE
$7,399
From 2,855
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 27 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$614
BALCONY
$742
SUITE
$1,445
From 614
View Trip
8 Day Italy And Adriatic with Cunard
Cruise

8 Days (7 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 27 July 2026
Countries Visited: Spain, Italy, Sicily, Greece (+1 more), Montenegro
INSIDE
$1,783
OCEANVIEW
$1,981
BALCONY
$2,179
SUITE
$4,951
From 1,783
View Trip
29 Day Mediterranean And Greek Islands with Cunard
Cruise

29 Days (28 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 04 May 2026
Countries Visited: Spain, Greece, Turkey, France (+3 more), Italy, Corsica, Sicily
INSIDE
$5,602
OCEANVIEW
$6,147
BALCONY
$7,137
SUITE
$14,859
From 5,602
View Trip
4 Day Mediterranean with MSC Cruises
Cruise

4 Days (3 Nights) Barcelona to Naples
Cruise Line: MSC Cruises
Ship: MSC Fantasia
Departure: 23 April 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$530
OCEANVIEW
$699
BALCONY
$758
SUITE
$1,104
From 530
View Trip
3 Day Mediterranean with MSC Cruises
Cruise

3 Days (2 Nights) Valencia to Genoa
Cruise Line: MSC Cruises
Ship: MSC Grandiosa
Departure: 06 November 2025
Countries Visited: Spain, France, Italy
Exclusive Deal
INSIDE
$384
OCEANVIEW
$463
BALCONY
$542
SUITE
$958
From 384
View Trip
8 Day Italy, France And Spain with Cunard
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departures: May 2026 to Jun 2026
Countries Visited: Spain, Corsica, Sicily, Italy
INSIDE
$1,387
OCEANVIEW
$1,585
BALCONY
$1,783
SUITE
$3,763
From 1,387
View Trip
8 Day A Journey From Barcelona To Rome with Explora Journeys
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Explora Journeys
Ship: Explora II
Departure: 13 May 2025
Countries Visited: Spain, France, Corsica, Sardinia (+1 more), Italy
Unique Escapes
INSIDE
-
OCEANVIEW
-
BALCONY
$6,192
SUITE
$7,529
From 6,192
View Trip
5 Day Europe - Western Mediterranean with Norwegian Cruise Line
Cruise

5 Days (4 Nights) Barcelona to Rome
Ship: Norwegian Escape
Departures: Jul 2024 to Sep 2024
Countries Visited: Spain, France, Italy
INSIDE
$1,561
OCEANVIEW
$1,760
BALCONY
$1,990
SUITE
$2,066
From 1,561
View Trip
29 Day Istanbul, Greek Islands And Mediterranean with Cunard
Cruise

29 Days (28 Nights) Barcelona to Rome
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 07 September 2026
Countries Visited: Spain, Corsica, Sicily, Italy (+3 more), France, Greece, Turkey
INSIDE
$6,246
OCEANVIEW
$6,741
BALCONY
$7,731
SUITE
$17,829
From 6,246
View Trip
6 Day France & Italy Cruise with Royal Caribbean
Cruise

6 Days (5 Nights) Barcelona to Ravenna
Cruise Line: Royal Caribbean
Ship: Explorer of the Seas
Departure: 12 May 2025
Countries Visited: Spain, Corsica, Italy, Sicily
Exclusive Deal
INSIDE
$1,533
OCEANVIEW
$1,998
BALCONY
$2,075
SUITE
$3,443
Save 581
From 1,327
View Trip
13 Day Barcelona to Rome with Silversea
Cruise

13 Days (12 Nights) Barcelona to Rome
Cruise Line: Silversea
Ship: Silver Ray
Departure: 18 May 2025
Countries Visited: Spain, France, Monaco, Italy
Port-to-PortDoor-to-Door Upgrade Option
INSIDE
-
OCEANVIEW
-
BALCONY
-
SUITE
$18,315
From 18,315
View Trip
11 Day Mediterranean Jewels & Malta with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 20 October 2024
Countries Visited: Spain, Tunisia, Italy, Malta
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$10,701
SUITE
$16,740
From 10,701
View Trip
15 Day France, Italy And Adriatic with Cunard
Cruise

15 Days (14 Nights) Barcelona to Trieste
Cruise Line: Cunard
Ship: Queen Victoria
Departure: 08 September 2025
Countries Visited: Spain, Sardinia, Corsica, Sicily (+4 more), Italy, Greece, Montenegro, Croatia
INSIDE
$2,627
OCEANVIEW
$2,855
BALCONY
$3,340
SUITE
$7,043
From 2,627
View Trip
11 Day Greek Isles & Turkey Cruise with Celebrity Cruises
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Celebrity Cruises
Ship: Celebrity Equinox
Departures: May 2025 to Oct 2025
Countries Visited: Spain, Greece, Turkey, Italy
Exclusive DealExclusive Offer
INSIDE
$2,494
OCEANVIEW
$3,055
BALCONY
$3,169
SUITE
$8,475
Save 3,803
From 2,494
View Trip
8 Day Mediterranean with MSC Cruises
Cruise

8 Days (7 Nights) Valencia to Venice
Cruise Line: MSC Cruises
Ship: MSC Opera
Departure: 27 March 2025
Countries Visited: Spain, Sicily, Greece, Italy (+1 more), Croatia
Early Booking Offer
INSIDE
$1,405
OCEANVIEW
$1,751
BALCONY
$2,682
SUITE
$4,088
From 1,405
View Trip
21 Day France & Spanish Treasures with Seabourn
Cruise

21 Days (20 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departure: 10 October 2024
Countries Visited: Spain, France, Tunisia, Italy (+2 more), Sicily, Malta
More Moments On Us Offer
INSIDE
-
OCEANVIEW
-
BALCONY
$19,126
SUITE
-
From 19,126
View Trip
8 Day Western Mediterranean with Royal Caribbean
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Royal Caribbean
Ship: Voyager of the Seas
Departure: 30 September 2024
Countries Visited: Spain, France, Corsica, Italy
Exclusive Deal
INSIDE
$2,102
OCEANVIEW
$2,743
BALCONY
$2,733
SUITE
$4,649
Save 782
From 1,722
View Trip
8 Day Florence, Rome, Palma & More with Virgin Voyages
Cruise

8 Days (7 Nights) Barcelona to Rome
Cruise Line: Virgin Voyages
Ship: Scarlet Lady
Departure: 29 June 2025
Countries Visited: Spain, France, Corsica, Italy
Up to 80% Off Second Sailor + Free Upgrade
INSIDE
$2,288
OCEANVIEW
$2,679
BALCONY
$2,951
SUITE
$6,552
From 2,288
View Trip
11 Day Mediterranean Overture with Seabourn
Cruise

11 Days (10 Nights) Barcelona to Rome
Cruise Line: Seabourn
Ship: Ovation
Departures: May 2025 to Oct 2025
Countries Visited: Spain, France, Monaco, Italy (+2 more), Corsica, Sardinia
The Sail Away Event
INSIDE
-
OCEANVIEW
-
BALCONY
$8,424
SUITE
$15,913
From 8,424
View Trip
5 Day MSC Grand Voyages with MSC Cruises
Cruise

5 Days (4 Nights) Alicante to Rome
Cruise Line: MSC Cruises
Ship: MSC Magnifica
Departure: 26 November 2024
Countries Visited: Spain, Italy
Exclusive Deal
INSIDE
-
OCEANVIEW
$610
BALCONY
$768
SUITE
$1,441
From 610
View Trip
Results: 61-90 of 109

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